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Prolymphocytic leukaemia and Hodgkin’s lymphoma

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Date
2002-09
ICR Author
Matutes, Estella
Author
Naranjo, TA
Matutes, E
Martinez, JJ
Ferre, LF
Domingo, A
Princep, RB
Usach, TS
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Type
Journal Article
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Abstract
We describe a case of B-prolymphocytic leukaemia (B-PLL) who, following a long-lasting remission with fluradabine, developed a Hodgkin’s lymphoma (HL) with bone marrow involvement. A 75-yr-old male was found to have a lymphocytosis [white blood cell (WBC) count = 146 x 10(9) L-1], small volume axillary lymphadenopathy, and hepatosplenomegaly. The majority of circulating lymphocytes had a round nucleus and prominent single nucleolus. The patient did not respond to chlorambucil and then received fludarabine, achieving a good response lasting for 5 yr, when he manifested with B symptoms and pancytopenia. A diagnosis of HL in the bone marrow was made based on histology (Reed Sternberg cells) and immunohistochemistry (CD30(+), CD15(+)). Epstein-Barr virus (EBV) studies were negative. The patient was treated with chemotherapy but died 6 months later from disease progression.
URI
https://repository.icr.ac.uk/handle/internal/2721
DOI
https://doi.org/10.1034/j.1600-0609.2002.02758.x
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  • Clinical Studies
  • Molecular Pathology
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
License start date
2002-09
Citation
EUROPEAN JOURNAL OF HAEMATOLOGY, 2002, 69 pp. 182 - 184

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