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Controversies and advances in the management of Wilms’ tumour

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Date
2002-09
ICR Author
Pritchard-Jones, Kathy
Author
Pritchard-Jones, K
Type
Journal Article
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Abstract
Wilms tumour is one of the success stories of paediatric oncology with long term survival approaching 90% in localised disease and over 70% for metastatic disease. Although appearing relatively simple compared to other cancer treatment regimens, successful treatment of Wilms tumour requires meticulous attention to correct staging of the tumour and good communication between the paediatric surgeon, pathologist and oncologist. The controversy of whether pre-operative chemotherapy results in a reduced overall burden of treatment compared to immediate nephrectomy has been addressed by the recently closed UKW3 randomised trial. Challenges remain in identification of histological and molecular risk factors for stratification of treatment intensity to allow safe reduction in therapy and avoidance of late sequelae for the majority while leading to increased biological insights and ultimately hovel therapies for the minority of high risk tumours. Genetic predisposition to Wilms tumour is conferred by several genes, some of which cause malformation rather than cancer and may be of low penetrance. The proportion of children with heritable disease is uncertain and there remains a need to collect data on the need for screening, in this susceptible population.
URI
https://repository.icr.ac.uk/handle/internal/2725
DOI
https://doi.org/10.1136/adc.87.3.241
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  • Other ICR Research
Language
eng
License start date
2002-09
Citation
ARCHIVES OF DISEASE IN CHILDHOOD, 2002, 87 pp. 241 - 244
Publisher
BRITISH MED JOURNAL PUBL GROUP

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