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dc.contributor.authorGruszka-Westwood, AMen_US
dc.contributor.authorHamoudi, Ren_US
dc.contributor.authorOsborne, Len_US
dc.contributor.authorMatutes, Een_US
dc.contributor.authorCatovsky, Den_US
dc.identifier.citationGENES CHROMOSOMES & CANCER, 2003, 36 pp. 57 - 69en_US
dc.description.abstractSplenic lymphoma with villous lymphocytes (SLVL) is a low-grade lymphoproliferative disorder characterized by splenomegaly and circulating villous lymphocytes in the peripheral blood. It is considered to be the leukemic form of splenic marginal zone lymphoma (SMZL). The genetic basis of this lymphoma type remains unknown. Conventional cytogenetic studies. have identified frequent structural abnormalities of chromosome 7, in the form of translocations, mainly unbalanced, and 7q deletions. In this current study, we undertook deletion mapping of the long arm of chromosome 7 in a series of cases with SLVL. Metaphase fluorescence in situ hybridization (FISH) was used in the first instance, followed by a study of loss of heterozygosity (LOH). The common area of deletion identified by FISH spanned from the YAC clone HSC7E1289 (mapping to 7q32.1) to in between YACs HSC7E195 and HSC7E648 (7q32-3). By application of 50 microsatellite markers mapping to the FISH-CDR and to areas of deletion reported in other studies, four distinct hotspot loci were identified, with abnormalities present in 29-55% cases. In three of them, both LOH and biallelic deletions were found. The LOH in the majority of patients was noncontiguous. The presence of a high incidence of abnormalities in the established hotspot areas and in particular the finding of biallelic deletions is indicative of the existence of genes important for the pathogenesis of SLVL in these areas. (C) 2003 Wiley-Liss, Inc.en_US
dc.format.extent57 - 69en_US
dc.titleDeletion mapping on the long arm of chromosome 7 in splenic lymphoma with villous lymphocytesen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesaffiliation: Catovsky, D (Reprint Author), Royal Marsden NHS Trust, Acad Dept Haematol & Cytogenet, Inst Canc Res, 203 Fulham Rd, London SW3 6JJ, England. Royal Marsden NHS Trust, Acad Dept Haematol & Cytogenet, Inst Canc Res, London SW3 6JJ, England. Univ Toronto, Dept Med, Toronto, ON, Canada. keywords-plus: MARGINAL-ZONE LYMPHOMA; CHRONIC LYMPHOPROLIFERATIVE DISORDERS; UTERINE LEIOMYOMAS; CUTL1 GENE; CELL; HETEROZYGOSITY; ABNORMALITIES; DELINEATION; DEL(7)(Q32) research-areas: Oncology; Genetics & Heredity web-of-science-categories: Oncology; Genetics & Heredity orcid-numbers: Gruszka, Alicja M/0000-0002-5359-0281 number-of-cited-references: 21 times-cited: 24 usage-count-last-180-days: 0 usage-count-since-2013: 1 journal-iso: Gene Chromosomes Cancer doc-delivery-number: 619QM unique-id: ISI:000179487700007 da: 2018-09-17en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorCatovsky, Danielen_US
dc.contributor.icrauthorMatutes, Estellaen_US
dc.contributor.icrauthorGruszka-Westwood, Alicjaen_US

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