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dc.contributor.authorJoshi, CVen_US
dc.contributor.authorEnver, Ten_US
dc.date.accessioned2018-09-17T15:15:05Z
dc.date.issued2002en_US
dc.identifier6en_US
dc.identifier.citationCurrent Opinion in Cell Biology, 2002, 14 pp. 749 - 755en_US
dc.identifier.issn0955-0674en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2733
dc.identifier.doi10.1016/S0955-0674(02)00392-7en_US
dc.description.abstractDespite some recent setbacks, it remains clear that adult stem cells under appropriate experimental conditions can at some frequency exhibit a wider range of differentiation potentials than previously appreciated. This is underscored by the recent demonstration of the extensive differentiation potential of mesenchymal stem cells. In terms of mechanism, it remains unclear in many cases to what extent plasticity reflects in vitro adaptation, transdifferentiation/cell-type switching or the persistence in adult tissues of stem cells with extensive endogenous or bona fide developmental potentials. These issues will need to be resolved before the full therapeutic potential of adult-derived stem cells can be realised.en_US
dc.format.extent749 - 755en_US
dc.titlePlasticity revisiteden_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/S0955-0674(02)00392-7en_US
rioxxterms.licenseref.startdate2002en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCurrent Opinion in Cell Biologyen_US
pubs.noteskeywords: mesenchymal stem cells, transdifferentiation, nuclear reprogramming, transcription factors, lineage specification, metaplasia, cancer, bone marrowen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume14en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorEnver, Tariqen_US


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