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Wnt signal transduction: kinase cogs in a nano-machine?

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Date
2002
ICR Author
Dale, Trevor
Author
Ding, Y
Dale, T
Type
Journal Article
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Abstract
The control of β-catenin levels is vital to the cell. The primary means of regulation is through ubiquitin-mediated degradation. This process is regulated by Wnt signalling and is frequently disrupted in cancer. Three recent papers show that the initial step in marking β-catenin for degradation involves phosphorylation by casein kinase 1. This then allows phosphorylation by glycogen synthase kinase-3, and the recruitment of ubiquitin-ligase components.
URI
https://repository.icr.ac.uk/handle/internal/2740
DOI
https://doi.org/10.1016/S0968-0004(02)02137-0
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  • Other ICR Research
Language
eng
License start date
2002
Citation
Trends in Biochemical Sciences, 2002, 27 pp. 327 - 329

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