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Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations

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Date
2003-02
ICR Author
Matutes, Estella
Author
Tierens, A
Delabie, J
Malecka, A
Wang, JB
Gruszka-Westwood, A
Catovsky, D
Matutes, E
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Type
Journal Article
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Abstract
Splenic marginal zone lymphoma (also splenic lymphoma with villous lymphocytes) is a B-cell nonHodgkin’s lymphoma with a characteristic morphology and phenotype. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases show immunoglobulin gene mutations, half of which show evidence of antigen selection, whereas one-third of the cases show no significant mutations. On-going mutation, a feature characteristic of follicular lymphoma, was demonstrated in all six cases randomly selected for this analysis, including one case with a low number of mutations (<2%). No statistical significant correlation was found between immunoglobulin mutation status and clinical, immunophenotypic, or genetic characteristics. Our results demonstrate that on-going somatic hypermutation is a prominent feature of splenic marginal zone lymphoma with circulating villous lymphocytes. On-going somatic hypermutation has previously been demonstrated in extra-nodal and nodal marginal zone lymphoma. Our results indicate that marginal zone lymphomas at different anatomical localizations may derive from a similar B-cell subset.
URI
https://repository.icr.ac.uk/handle/internal/2742
DOI
https://doi.org/10.1016/S0002-9440(10)63862-X
Collections
  • Clinical Studies
  • Molecular Pathology
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
License start date
2003-02
Citation
AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 pp. 681 - 689
Publisher
AMER SOC INVESTIGATIVE PATHOLOGY, INC

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