dc.contributor.author | Tierens, A | |
dc.contributor.author | Delabie, J | |
dc.contributor.author | Malecka, A | |
dc.contributor.author | Wang, JB | |
dc.contributor.author | Gruszka-Westwood, A | |
dc.contributor.author | Catovsky, D | |
dc.contributor.author | Matutes, E | |
dc.date.accessioned | 2018-09-17T15:17:11Z | |
dc.date.issued | 2003-02 | |
dc.identifier | 2 | |
dc.identifier.citation | AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 pp. 681 - 689 | |
dc.identifier.issn | 0002-9440 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2742 | |
dc.identifier.doi | 10.1016/S0002-9440(10)63862-X | |
dc.description.abstract | Splenic marginal zone lymphoma (also splenic lymphoma with villous lymphocytes) is a B-cell nonHodgkin’s lymphoma with a characteristic morphology and phenotype. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases show immunoglobulin gene mutations, half of which show evidence of antigen selection, whereas one-third of the cases show no significant mutations. On-going mutation, a feature characteristic of follicular lymphoma, was demonstrated in all six cases randomly selected for this analysis, including one case with a low number of mutations (<2%). No statistical significant correlation was found between immunoglobulin mutation status and clinical, immunophenotypic, or genetic characteristics. Our results demonstrate that on-going somatic hypermutation is a prominent feature of splenic marginal zone lymphoma with circulating villous lymphocytes. On-going somatic hypermutation has previously been demonstrated in extra-nodal and nodal marginal zone lymphoma. Our results indicate that marginal zone lymphomas at different anatomical localizations may derive from a similar B-cell subset. | |
dc.format.extent | 681 - 689 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER SOC INVESTIGATIVE PATHOLOGY, INC | |
dc.title | Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1016/S0002-9440(10)63862-X | |
rioxxterms.licenseref.startdate | 2003-02 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | AMERICAN JOURNAL OF PATHOLOGY | |
pubs.notes | affiliation: Delabie, J (Reprint Author), Norweigian Canc Inst, Dept Pathol, N-0310 Oslo, Norway. Norweigian Canc Inst, Dept Pathol, N-0310 Oslo, Norway. Norweigian Canc Inst, Dept Tumor Biol, N-0310 Oslo, Norway. Univ Oslo, Radiumhosp, Oslo, Norway. Royal Marsden Hosp, London SW3 6JJ, England. keywords-plus: X-LINKED IMMUNODEFICIENCY; VARIABLE REGION GENES; HYPER-IGM SYNDROME; B-CELL LYMPHOMAS; V-H GENES; CD40 LIGAND; DIFFERENTIAL-DIAGNOSIS; ANTIGEN SELECTION; ONGOING MUTATION; CLONAL EXPANSION research-areas: Pathology web-of-science-categories: Pathology researcherid-numbers: Wang, Junbai/B-2093-2008 orcid-numbers: Delabie, Jan/0000-0001-5023-0689 Gruszka, Alicja M/0000-0002-5359-0281 number-of-cited-references: 52 times-cited: 38 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Am. J. Pathol. doc-delivery-number: 638NL unique-id: ISI:000180577100033 oa: green_published da: 2018-09-17 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers) | |
pubs.volume | 162 | en_US |
pubs.embargo.terms | Not known | |
icr.researchteam | Molecular Haematology (including Cytogenetics Group and Cell Markers) | en_US |
dc.contributor.icrauthor | Matutes, Estella | en |