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dc.contributor.authorTierens, Aen_US
dc.contributor.authorDelabie, Jen_US
dc.contributor.authorMalecka, Aen_US
dc.contributor.authorWang, JBen_US
dc.contributor.authorGruszka-Westwood, Aen_US
dc.contributor.authorCatovsky, Den_US
dc.contributor.authorMatutes, Een_US
dc.date.accessioned2018-09-17T15:17:11Z
dc.date.issued2003-02en_US
dc.identifier2en_US
dc.identifier.citationAMERICAN JOURNAL OF PATHOLOGY, 2003, 162 pp. 681 - 689en_US
dc.identifier.issn0002-9440en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2742
dc.identifier.doi10.1016/S0002-9440(10)63862-Xen_US
dc.description.abstractSplenic marginal zone lymphoma (also splenic lymphoma with villous lymphocytes) is a B-cell nonHodgkin’s lymphoma with a characteristic morphology and phenotype. We studied the pattern of somatic hypermutation of the rearranged immunoglobulin heavy chain genes on 23 cases and have correlated these data with survival as well as immunophenotypic and genetic characteristics of the cases. Two-thirds of the cases show immunoglobulin gene mutations, half of which show evidence of antigen selection, whereas one-third of the cases show no significant mutations. On-going mutation, a feature characteristic of follicular lymphoma, was demonstrated in all six cases randomly selected for this analysis, including one case with a low number of mutations (<2%). No statistical significant correlation was found between immunoglobulin mutation status and clinical, immunophenotypic, or genetic characteristics. Our results demonstrate that on-going somatic hypermutation is a prominent feature of splenic marginal zone lymphoma with circulating villous lymphocytes. On-going somatic hypermutation has previously been demonstrated in extra-nodal and nodal marginal zone lymphoma. Our results indicate that marginal zone lymphomas at different anatomical localizations may derive from a similar B-cell subset.en_US
dc.format.extent681 - 689en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherAMER SOC INVESTIGATIVE PATHOLOGY, INCen_US
dc.titleSplenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutationsen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/S0002-9440(10)63862-Xen_US
rioxxterms.licenseref.startdate2003-02en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAMERICAN JOURNAL OF PATHOLOGYen_US
pubs.notesaffiliation: Delabie, J (Reprint Author), Norweigian Canc Inst, Dept Pathol, N-0310 Oslo, Norway. Norweigian Canc Inst, Dept Pathol, N-0310 Oslo, Norway. Norweigian Canc Inst, Dept Tumor Biol, N-0310 Oslo, Norway. Univ Oslo, Radiumhosp, Oslo, Norway. Royal Marsden Hosp, London SW3 6JJ, England. keywords-plus: X-LINKED IMMUNODEFICIENCY; VARIABLE REGION GENES; HYPER-IGM SYNDROME; B-CELL LYMPHOMAS; V-H GENES; CD40 LIGAND; DIFFERENTIAL-DIAGNOSIS; ANTIGEN SELECTION; ONGOING MUTATION; CLONAL EXPANSION research-areas: Pathology web-of-science-categories: Pathology researcherid-numbers: Wang, Junbai/B-2093-2008 orcid-numbers: Delabie, Jan/0000-0001-5023-0689 Gruszka, Alicja M/0000-0002-5359-0281 number-of-cited-references: 52 times-cited: 38 usage-count-last-180-days: 0 usage-count-since-2013: 0 journal-iso: Am. J. Pathol. doc-delivery-number: 638NL unique-id: ISI:000180577100033 oa: green_published da: 2018-09-17en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular Haematology (including Cytogenetics Group and Cell Markers)
pubs.volume162en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular Haematology (including Cytogenetics Group and Cell Markers)en_US
dc.contributor.icrauthorMatutes, Estellaen_US


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