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Smoking-related DNA and protein adducts in human tissues

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Date
2002-12
ICR Author
Phillips, David Hunter
Author
Phillips, DH
Type
Journal Article
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Abstract
Tobacco smoking causes not only lung cancer but also cancer of the oral and nasal cavities, oesophagus, larynx, pharynx, pancreas, liver, kidney, stomach, urinary tract and cervix. Tobacco smoke contains many carcinogens that exert their biological effects through interaction of reactive intermediates with DNA to form DNA adducts. The same electrophilic species also react with cellular proteins. The effects of smoking are evident by the detection of elevated levels of carcinogen-DNA adducts in many human tissues and of carcinogen-protein adducts in blood. Components of tobacco smoke also induce oxidative DNA damage. Systemic exposure to tobacco-derived carcinogens is demonstrated by the observation of elevated levels of DNA adducts in tissues not directly exposed to tobacco smoke. For many of these tissues there is epidemiological evidence, varying from comprehensive to preliminary, that smoking is a causative factor in cancer of that site. The effects of passive smoking, which also causes lung cancer in nonsmokers, is also evident in elevated levels of protein adducts in exposed non-smokers so exposed, relative to non-exposed non-smokers. This paper reviews the literature on smoking-related DNA and protein adducts in human tissues and shows how such studies have provided mechanistic insight into the epidemiological associations between smoking and cancer.
URI
https://repository.icr.ac.uk/handle/internal/2748
DOI
https://doi.org/10.1093/carcin/23.12.1979
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Research team
Human Biomonitoring & Carcinogen Activation
Language
eng
License start date
2002-12
Citation
CARCINOGENESIS, 2002, 23 pp. 1979 - 2004
Publisher
OXFORD UNIV PRESS

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