| dc.contributor.author | Ahmed, S | |
| dc.contributor.author | James, K | |
| dc.contributor.author | Owen, CP | |
| dc.contributor.author | Patel, CK | |
| dc.date.accessioned | 2018-09-18T10:11:41Z | |
| dc.date.issued | 2002-05-20 | |
| dc.identifier | 10 | |
| dc.identifier.citation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 pp. 1343 - 1346 | |
| dc.identifier.issn | 0960-894X | |
| dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2760 | |
| dc.identifier.doi | 10.1016/S0960-894X(02)00170-1 | |
| dc.description.abstract | We report the initial results of our study into a series of simple 4’-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic derivative of COUMATE. namely 667-COUMATE. Furthermore, the compounds are observed to be irreversible inhibitors. (C) 2002 Elsevier Science Ltd. All rights reserved. | |
| dc.format.extent | 1343 - 1346 | |
| dc.language | eng | |
| dc.language.iso | eng | |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | |
| dc.title | Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES) | |
| dc.type | Journal Article | |
| rioxxterms.versionofrecord | 10.1016/S0960-894X(02)00170-1 | |
| rioxxterms.licenseref.startdate | 2002-05-20 | |
| rioxxterms.type | Journal Article/Review | |
| dc.relation.isPartOf | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | |
| pubs.notes | affiliation: Ahmed, S (Reprint Author), Kingston Univ, Sch Chem & Pharmaceut Sci, Penrhyn Rd, Kingston upon Thames KT1 2EE, Surrey, England. Kingston Univ, Sch Chem & Pharmaceut Sci, Kingston upon Thames KT1 2EE, Surrey, England. Inst Canc Res, Sutton, Surrey, England. article-number: PII S0960-894X(02)00170-1 keywords-plus: NONSTEROIDAL INHIBITORS; STEROID SULFATASE research-areas: Pharmacology & Pharmacy; Chemistry web-of-science-categories: Chemistry, Medicinal; Chemistry, Organic number-of-cited-references: 9 times-cited: 11 usage-count-last-180-days: 0 usage-count-since-2013: 2 journal-iso: Bioorg. Med. Chem. Lett. doc-delivery-number: 552YX unique-id: ISI:000175648800005 da: 2018-09-18 | |
| pubs.notes | Not known | |
| pubs.organisational-group | /ICR | |
| pubs.organisational-group | /ICR | |
| pubs.volume | 12 | |
| pubs.embargo.terms | Not known | |
| dc.contributor.icrauthor | James, Karen | |
