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Rho GTPase signalling pathways in the morphological changes associated with apoptosis

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Date
2002-05
ICR Author
Olson, Michael
Author
Coleman, ML
Olson, MF
Type
Journal Article
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Abstract
The killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture, In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.
URI
https://repository.icr.ac.uk/handle/internal/2763
DOI
https://doi.org/10.1038/sj.cdd.4400987
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  • Other ICR Research
Language
eng
License start date
2002-05
Citation
CELL DEATH AND DIFFERENTIATION, 2002, 9 pp. 493 - 504
Publisher
NATURE PUBLISHING GROUP

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