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dc.contributor.authorColeman, MLen_US
dc.contributor.authorOlson, MFen_US
dc.date.accessioned2018-09-18T10:35:54Z
dc.date.issued2002-05en_US
dc.identifier5en_US
dc.identifier.citationCELL DEATH AND DIFFERENTIATION, 2002, 9 pp. 493 - 504en_US
dc.identifier.issn1350-9047en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2763
dc.identifier.doi10.1038/sj.cdd.4400987en_US
dc.description.abstractThe killing and removal of superfluous cells is an important step during embryonic development, tissue homeostasis, wound repair and the resolution of inflammation. A specific sequence of biochemical events leads to a form of cell death termed apoptosis, and ultimately to the disassembly of the dead cell for phagocytosis. Dynamic rearrangements of the actin cytoskeleton are central to the morphological changes observed both in apoptosis and phagocytosis. Recent research has highlighted the importance of Rho GTPase signalling pathways to these changes in cellular architecture, In this review, we will discuss how these signal transduction pathways affect the structure of the actin cytoskeleton and allow for the efficient clearance of apoptotic cells.en_US
dc.format.extent493 - 504en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.titleRho GTPase signalling pathways in the morphological changes associated with apoptosisen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/sj.cdd.4400987en_US
rioxxterms.licenseref.startdate2002-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfCELL DEATH AND DIFFERENTIATIONen_US
pubs.notesaffiliation: Olson, MF (Reprint Author), Univ Penn, Abramson Family Canc Res Inst, Room 411,BRB 2-3,421 Curie Blvd, Philadelphia, PA 19104 USA. Inst Canc Res, Canc Res Campaign, Ctr Cell & Mol Biol, London SW3 6JB, England. keywords: Rho; Rac; ROCK; actin cytoskeleton; myosin light chain; phagocytosis; blebbing keywords-plus: RECEPTOR-MEDIATED PHAGOCYTOSIS; GDP-DISSOCIATION INHIBITOR; PROGRAMMED CELL-DEATH; ACTIN STRESS FIBERS; BINDING PROTEIN-RHO; LIGHT-CHAIN PHOSPHORYLATION; CASPASE-DEPENDENT CLEAVAGE; FOCAL ADHESION KINASE; FAS-INDUCED APOPTOSIS; C-RELATED KINASE-2 research-areas: Biochemistry & Molecular Biology; Cell Biology web-of-science-categories: Biochemistry & Molecular Biology; Cell Biology researcherid-numbers: Coleman, Mathew/C-1676-2014 Olson, Michael/A-3240-2011 orcid-numbers: Coleman, Mathew/0000-0001-6020-9023 Olson, Michael/0000-0003-3428-3507 number-of-cited-references: 162 times-cited: 165 usage-count-last-180-days: 0 usage-count-since-2013: 11 journal-iso: Cell Death Differ. doc-delivery-number: 546EV unique-id: ISI:000175260000005 oa: gold_or_bronze da: 2018-09-18en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume9en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorOlson, Michaelen_US


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