Telomere maintenance as a target for anticancer drug discovery
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Maintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells that have been examined so far, but is absent in most normal cells. So, targeting telomere-maintenance mechanisms could potentially halt tumour growth across a broad spectrum of tumour types, with little cytotoxic effect outside tumours. Here, we describe the current understanding of telomere biology, and the application of this knowledge to the development of anticancer drugs.
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NATURE REVIEWS DRUG DISCOVERY, 2002, 1 pp. 383 - 393
NATURE PUBLISHING GROUP