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dc.contributor.authorNeidle, Sen_US
dc.contributor.authorParkinson, Gen_US
dc.date.accessioned2018-09-18T10:36:00Z
dc.date.issued2002-05en_US
dc.identifier5en_US
dc.identifier.citationNATURE REVIEWS DRUG DISCOVERY, 2002, 1 pp. 383 - 393en_US
dc.identifier.issn1474-1776en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2764
dc.identifier.doi10.1038/nrd793en_US
dc.description.abstractMaintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells that have been examined so far, but is absent in most normal cells. So, targeting telomere-maintenance mechanisms could potentially halt tumour growth across a broad spectrum of tumour types, with little cytotoxic effect outside tumours. Here, we describe the current understanding of telomere biology, and the application of this knowledge to the development of anticancer drugs.en_US
dc.format.extent383 - 393en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.titleTelomere maintenance as a target for anticancer drug discoveryen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/nrd793en_US
rioxxterms.licenseref.startdate2002-05en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNATURE REVIEWS DRUG DISCOVERYen_US
pubs.notesaffiliation: Neidle, S (Reprint Author), Inst Canc Res, Chester Beatty Labs, CRC, Biomol Struct Unit, 237 Fulham Rd, London SW3 6JB, England. Inst Canc Res, Chester Beatty Labs, CRC, Biomol Struct Unit, London SW3 6JB, England. keywords-plus: G-QUADRUPLEX DNA; HUMAN TUMOR-CELLS; CATIONIC PORPHYRINS; SMALL-MOLECULE; POLY(ADP-RIBOSE) POLYMERASE; FISSION YEAST; C-MYC; INHIBITION; LENGTH; END research-areas: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy web-of-science-categories: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy number-of-cited-references: 80 times-cited: 513 usage-count-last-180-days: 8 usage-count-since-2013: 98 journal-iso: Nat. Rev. Drug Discov. doc-delivery-number: 607EB unique-id: ISI:000178777700020 da: 2018-09-18en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume1en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorNeidle, Stephenen_US


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