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dc.contributor.authorNeidle, S
dc.contributor.authorParkinson, G
dc.date.accessioned2018-09-18T10:36:00Z
dc.date.issued2002-05
dc.identifier5
dc.identifier.citationNATURE REVIEWS DRUG DISCOVERY, 2002, 1 pp. 383 - 393
dc.identifier.issn1474-1776
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2764
dc.identifier.doi10.1038/nrd793
dc.description.abstractMaintenance of telomeres - specialized complexes that protect the ends of chromosomes is undertaken by the enzyme complex telomerase, which is a key factor that is activated in more than 80% of cancer cells that have been examined so far, but is absent in most normal cells. So, targeting telomere-maintenance mechanisms could potentially halt tumour growth across a broad spectrum of tumour types, with little cytotoxic effect outside tumours. Here, we describe the current understanding of telomere biology, and the application of this knowledge to the development of anticancer drugs.
dc.format.extent383 - 393
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.titleTelomere maintenance as a target for anticancer drug discovery
dc.typeJournal Article
rioxxterms.versionofrecord10.1038/nrd793
rioxxterms.licenseref.startdate2002-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNATURE REVIEWS DRUG DISCOVERY
pubs.notesaffiliation: Neidle, S (Reprint Author), Inst Canc Res, Chester Beatty Labs, CRC, Biomol Struct Unit, 237 Fulham Rd, London SW3 6JB, England. Inst Canc Res, Chester Beatty Labs, CRC, Biomol Struct Unit, London SW3 6JB, England. keywords-plus: G-QUADRUPLEX DNA; HUMAN TUMOR-CELLS; CATIONIC PORPHYRINS; SMALL-MOLECULE; POLY(ADP-RIBOSE) POLYMERASE; FISSION YEAST; C-MYC; INHIBITION; LENGTH; END research-areas: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy web-of-science-categories: Biotechnology & Applied Microbiology; Pharmacology & Pharmacy number-of-cited-references: 80 times-cited: 513 usage-count-last-180-days: 8 usage-count-since-2013: 98 journal-iso: Nat. Rev. Drug Discov. doc-delivery-number: 607EB unique-id: ISI:000178777700020 da: 2018-09-18
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume1
pubs.embargo.termsNot known
dc.contributor.icrauthorNeidle, Stephenen


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