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dc.contributor.authorJolley, JNen_US
dc.contributor.authorYanovsky, AIen_US
dc.contributor.authorKelland, LRen_US
dc.contributor.authorNolan, KBen_US
dc.date.accessioned2018-09-18T10:36:32Z
dc.date.issued2001-01-15en_US
dc.identifier2-3en_US
dc.identifier.citationJOURNAL OF INORGANIC BIOCHEMISTRY, 2001, 83 pp. 91 - 100en_US
dc.identifier.issn0162-0134en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2769
dc.identifier.doi10.1016/S0162-0134(00)00190-2en_US
dc.description.abstractSeveral cisplatin analogues of ethylenediamine-derived ligands containing alcohol, carboxylic acid and acetate substituents have been prepared and characterised, Oxidation of some of these square planar platinum(II) complexes using aqueous hydrogen peroxide gave octahedral platinum(IV) complexes, containing trans hydroxo ligands. Acetylation of the hydroxo ligands was achieved by reaction with acetic anhydride, giving complexes which are analogues of the antitumour drug, JM-216. Oxidation of the complex [Pt(H2L4)Cl-2], where H2L4 is ethylenediamine-N,N’-diacetic acid, with H2O2 gave the platinum(IV) complex [(PtLCl2)-Cl-4].H2O in which L-4 is tetradentate as shown by a crystal and molecular structure. This complex was previously reported to be [Pt(HL4)(OH)Cl-2] in which HL4 is tridentate. Several of the complexes were tested for antitumour activity against five human ovarian carcinoma cell lines. IC50 values range from 4.0 muM for cis,trans-PtCl2(OH)(2)(NH2CH2CH2NHCH2CH2OH) against the CH1 cell line to >25 muM indicating moderate to low activity relative to other platinum complexes. (C) 2001 Elsevier Science B.V. All rights reserved.en_US
dc.format.extent91 - 100en_US
dc.titleSynthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents - Crystal and molecular structure of [(PtLCl2)-Cl-4]center dot H2O where L-4 is ethylenediamine-N,N ‘-diacetateen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/S0162-0134(00)00190-2en_US
rioxxterms.licenseref.startdate2001-01-15en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfJOURNAL OF INORGANIC BIOCHEMISTRYen_US
pubs.notesresearcherid-numbers: Nolan, Kevin/D-7669-2012 unique-id: ISI:000167256800003en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume83en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorKelland, Lloyden_US


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