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dc.contributor.authorJorge, SACen_US
dc.contributor.authorMenck, CFMen_US
dc.contributor.authorSies, Hen_US
dc.contributor.authorOsborne, MRen_US
dc.contributor.authorPhillips, DHen_US
dc.contributor.authorSarasin, Aen_US
dc.contributor.authorStary, Aen_US
dc.identifier.citationDNA Repair, 2002, 1 pp. 369 - 378en_US
dc.description.abstractOzone is an important factor in urban pollution and represents a major concern for human health. The chemical reactivity of ozone toward biological targets and particularly its genotoxicity supports a possible link between exposure and cancer risk, but no molecular data exist on its mutagenic potential in human cells. Using a shuttle vector, we showed that ozone is indeed a potent mutagen and we characterized the mutation spectrum it produced in human cells. Almost all mutations are base substitutions, essentially located at G:Cs (75%), typical of reactive oxygen species (ROS), but occurring in a specific pattern, i.e. a similar extent of GC:TA (28%), GC:CG (23%) and GC:AT (23%). The targeted distribution of mutations and identification of hotspot sequences define the first molecular fingerprint of mutations induced by ozone in human cells. Possible applications derived from our results with respect to ozone genotoxicity should help determining quantifiable biomarkers of ozone exposure in human health, especially for carcinogenesis.en_US
dc.format.extent369 - 378en_US
dc.titleMutagenic fingerprint of ozone in human cellsen_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfDNA Repairen_US
pubs.noteskeywords: DNA, Human cells, Ozone, Mutation, Shuttle vector, Reactive oxygen speciesen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Human Biomonitoring & Carcinogen Activation
pubs.embargo.termsNot knownen_US
icr.researchteamHuman Biomonitoring & Carcinogen Activationen_US
dc.contributor.icrauthorPhillips, David Hunteren_US
dc.contributor.icrauthorOsborne, Martinen_US

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