Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Closed Research Teams
  • View item
  • Home
  • ICR Divisions
  • Closed Research Teams
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

The expression patterns of integrin subunits on human breast tissues obtained during pregnancy

Thumbnail
Date
2002
ICR Author
Lakhani, Sunil
Author
Suzuki, RN
Entwistle, A
Atherton, AJ
Clarke, C
Lakhani, SR
O Hare, MJ
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Integrins have been shown to exert regulatory influences on mammary differentiation and morphogenesis in rodent experimental systems. We have, therefore, examined the expression patterns of integrin subunits on human breast tissues obtained at the 12th, 15th and 18th weeks of pregnancy. Myoepithelial cells were positive for all the integrin subunits examined. alpha2, alpha6 and beta4 showed increased and more defined labelling during pregnancy, indicating that myoepithelial cells and extracellular matrix strengthen their support for the expanding alveoli during pregnancy. Sub-populations of stromal cells were positive for alpha1, alpha3, alpha6, beta1 and beta4. On luminal epithelial cells, alpha1, alpha2, alpha3, alpha6 and beta1 were detectable. alpha2 showed a focal decrease, but the expression patterns of other integrins in luminal cells did not change during pregnancy. Therefore, the expression patterns of most integrins existing prior to pregnancy seem sufficient in this cell type to support the morphological and functional development during early pregnancy. (C) 2002 Elsevier Science Ltd. All rights reserved.
URI
https://repository.icr.ac.uk/handle/internal/2795
DOI
https://doi.org/10.1006/cbir.2002.0880
Collections
  • Closed Research Teams
Research team
Molecular Pathology
Language
eng
License start date
2002
Citation
CELL BIOLOGY INTERNATIONAL, 2002, 26 pp. 593 - 598
Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.