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dc.contributor.authorTsuzuki, Sen_US
dc.contributor.authorEnver, Ten_US
dc.date.accessioned2018-09-18T14:45:04Z
dc.date.issued2002-05-01en_US
dc.identifier9en_US
dc.identifier.citationBLOOD, 2002, 99 pp. 3404 - 3410en_US
dc.identifier.issn0006-4971en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2803
dc.identifier.doi10.1182/blood.V99.9.3404en_US
dc.description.abstractTranscription factor GATA-2 Is Implicated in the survival and growth of multipotential progenitors. Here we report that the promyelocytic leukemia zinc finger (PLZF) protein can Interact with GATA-2 and can modify Its transactivation capacity. Fanconi anemia zinc finger (FAZF), a PLZF-homologous protein that has been variously described as ROG (repressor of GATA), and TZFP (testis zinc finger protein) also Interact with GATA-2. The zinc finger region of GATA-2 Is required for binding to PLZF and FAZF, but distinct Interfaces on the PLZF and FAZF molecules mediate the Interaction, suggesting that GATA-2 activity Is controlled by these 2 homologous proteins through distinct mechanisms. GATA-2 can also physically associate with the PLZF-RARalpha fusion protein generated by the t(11;17) chromosomal translocation associated with acute promyelocytic leukemia (APL). Functional experiments showed that this Interaction has the capacity to render GATA-dependent transcription responsive to treatment with ill combination of all-trans retinoic acid and the histone deacetylase Inhibitor trichostatin A (TSA). This combination of drugs has been shown to stimulate the terminal differentiation of leukemic t(11;17)-associated APL blasts, raising the possibility that GATA target genes may be Involved In the molecular pathogenesis of APL. (C) 2002 by The American Society of Hematology.en_US
dc.format.extent3404 - 3410en_US
dc.titleInteractions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoproteinen_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1182/blood.V99.9.3404en_US
rioxxterms.licenseref.startdate2002-05-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBLOODen_US
pubs.notesunique-id: ISI:000175204300044en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume99en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorEnver, Tariqen_US


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