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Plasticity of Pax-5(-/-) pre-B I cells

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Date
2002
ICR Author
Ludovica, Bruno
Author
Bruno, L
Schaniel, C
Rolink, A
Type
Journal Article
Metadata
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Abstract
In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5(-/-) pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon. Copyright (C) 2002 S. Karger AG, Basel.
URI
https://repository.icr.ac.uk/handle/internal/2807
DOI
https://doi.org/10.1159/000057690
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  • Other ICR Research
Language
eng
License start date
2002
Citation
CELLS TISSUES ORGANS, 2002, 171 pp. 38 - 43
Publisher
KARGER

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