Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

New method for the preparation of 3 ‘- and 2 ‘-O-phosphoramidites of 2 ‘- and 3 ‘-difluoromethyluridine derivatives

Thumbnail
Date
2002
ICR Author
Serafinowski, Pawel
Author
Serafinowski, PJ
Brown, CA
Type
Journal Article
Metadata
Show full item record
Abstract
Hydrogenation of 2-deoxy-2’-difluoromethylene-5’-O-dimethoxytrityluridine (1) and 3’-deoxy-3’-difluoromethylene-5’-O-dimethoxytrityluridine (7), gave the corresponding 2- and 3’-difluoromethyluridine derivatives 2a and 8a. Detritylation of compounds 2a, 2b and 8a, 8b resulted in the formation of 1-(2-deoxy-2-C-difluoromethyl-beta-D-arabino-pentofuranosyl)uracil (3a) and 1-(3-deoxy-3-C-difluoromethyl-beta-D-xylo-pento furanosyl)- uracil (9a) as well as corresponding minor isomers 3b and 9b. Compounds 3a and 3b were also obtained from 2-deoxy-2’-difluoromethylene-3,5’-O-(tetra-isopropyldisiloxane-1,3-diyl) uridine (4). Finally, phosphitylation of 2a and 8a provided the title 2- and 3’-0-phosphorarnidites 6 and 10.
URI
https://repository.icr.ac.uk/handle/internal/2810
DOI
https://doi.org/10.1081/NCN-120006526
Collections
  • Other ICR Research
Language
eng
License start date
2002
Citation
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2002, 21 pp. 1 - 13

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.