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dc.contributor.authorArlt, VMen_US
dc.contributor.authorPfohl-Leszkowicz, Aen_US
dc.contributor.authorCosyns, Jen_US
dc.contributor.authorSchmeiser, HHen_US
dc.date.accessioned2018-09-24T15:50:01Z
dc.date.issued2001-07en_US
dc.identifier.citationMutation research, 2001, 494 (1-2), pp. 143 - 150en_US
dc.identifier.issn0027-5107en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2819
dc.identifier.eissn1873-135Xen_US
dc.identifier.doi10.1016/s1383-5718(01)00188-7en_US
dc.description.abstractChinese herbs nephropathy (CHN), a unique type of nephropathy has been associated with the intake of weight-reducing pills containing the Chinese herb Aristolochia fangchi. Moreover, an association between the use of A. fangchi and urothelial cancer in CHN patients has been reported indicating that aristolochic acid (AA) the major alkaloid of A. fangchi might be the causal agent. Similarities of CHN to the Balkan endemic nephropathy (BEN) have led to the hypothesis of a common etiological agent for both diseases. Evidence has accumulated that BEN is an environmentally-induced disease strongly associated with the fungal mycotoxin ochratoxin A (OTA). Both, AA and OTA are nephrotoxic and carcinogenic and induce the formation of DNA adducts. As OTA has been suspected as fungal contaminant in the herbal batches used for the preparation of the weight-reducing pills we analysed tissues from CHN patients by the 32P-postlabeling procedure for the presence of DNA adducts related to both OTA and AA exposure. Whereas, AA-specific DNA adducts were detected in all five urinary tract tissues from five patients (total RAL: 32-251 adducts per 10(9) nucleotides), OTA-related DNA adducts were detectable in two kidneys and one ureter only (total RAL: 1.5-3.7 adducts per 10(9) nucleotides). Thus, OTA-related DNA adduct levels were about 50 times lower than AA-DNA adduct levels. In female and male rats that were treated with the slimming regimen in the same way like the CHN patients except that the amount of Chinese herbs was 10 times higher, AA-DNA adducts were found in kidney tissues (total RAL ranging from 51 to 83 adducts per 10(9) nucleotides) but adducts derived from OTA were not observed. These results demonstrate that OTA-related DNA adducts do not play a key role in CHN or CHN-associated urothelial cancer.en_US
dc.formatPrinten_US
dc.format.extent143 - 150en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectAnimalsen_US
dc.subjectHumansen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectBalkan Nephropathyen_US
dc.subjectAristolochic Acidsen_US
dc.subjectOchratoxinsen_US
dc.subjectPhenanthrenesen_US
dc.subjectDNA Adductsen_US
dc.subjectAnti-Obesity Agentsen_US
dc.subjectDrugs, Chinese Herbalen_US
dc.subjectMycotoxinsen_US
dc.subjectAdulten_US
dc.subjectMiddle Ageden_US
dc.subjectBelgiumen_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectRenal Insufficiencyen_US
dc.titleAnalyses of DNA adducts formed by ochratoxin A and aristolochic acid in patients with Chinese herbs nephropathy.en_US
dc.typeJournal Article
rioxxterms.versionofrecord10.1016/s1383-5718(01)00188-7en_US
rioxxterms.licenseref.startdate2001-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfMutation researchen_US
pubs.issue1-2en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Human Biomonitoring & Carcinogen Activation
pubs.publication-statusPublisheden_US
pubs.volume494en_US
pubs.embargo.termsNot knownen_US
icr.researchteamHuman Biomonitoring & Carcinogen Activationen_US
dc.contributor.icrauthorArlt, Volker Manfreden_US


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