Show simple item record

dc.contributor.authorLiu, HX
dc.contributor.authorYe, HT
dc.contributor.authorDogan, A
dc.contributor.authorRanaldi, R
dc.contributor.authorHamoudi, RA
dc.contributor.authorBearzi, T
dc.contributor.authorIsaacson, PG
dc.contributor.authorDu, MQ
dc.date.accessioned2018-09-24T15:51:29Z
dc.date.issued2001-08-15
dc.identifier4
dc.identifier.citationBLOOD, 2001, 98 pp. 1182 - 1187
dc.identifier.issn0006-4971
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2831
dc.identifier.doi10.1182/blood.V98.4.1182en_US
dc.description.abstractThe development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is a multistep process and can be clinico-pathologically divided into Helicobacter pylori-associated gastritis, low-grade tumors, and high-grade tumors. The molecular events underlying this progression are largely unknown. However, identification of the genes involved in MALT lymphoma-specific t(11;18)(q21;q21) and t(1;14)(p22;q32) has provided fresh insights into the pathogenesis of this disease. T(11;18)(q21;q21) results in a chimeric transcript between the API2 and the MALT1 genes, whereas t(1;14) (p22;q32) causes aberrant nuclear BCL10 expression. Significantly, nuclear BCL10 expression also occurs frequently in MALT lymphomas without t(1;14)(p22; q32), suggesting an important role for BCL10 in lymphoma development. Thirty-three cases of H pylori gastritis, 72 MALT lymphomas, and 11 mucosal diffuse large B-cell lymphomas (DLBCL) were screened for t(11;18)(q21;q21) by reverse transcription-polymerase chain reaction followed by sequencing. BCL10 expression in lymphoma cases was examined by immunohistochemistry. The API2-MALT1 fusion transcript was not detected in H pylori gastritis and mucosal DLBCL but was found in 25 of 72 (35%) MALT lymphomas of various sites. Nuclear BCL10 expression was seen in 28 of 53 (53%) of MALT lymphomas. Of the gastric cases, the largest group studied, the frequency of both t(11;18)(q21;q21) and nuclear BCL10 expression was significantly higher in tumors that showed dissemination to local lymph nodes or distal sites (14 of 18 = 78% and 14 of 15 = 93%, respectively) than those confined to the stomach (3 of 29 = 10% and 10 of 26 = 38%). Furthermore, t(11;18)(q21;q21) closely correlated with BCL10 nuclear expression. These results indicate that both t(11;18)(q21;q21) and BCL10 nuclear expression are associated with advanced MALT lymphoma and that their oncogenic activities may be related to each other.
dc.format.extent1182 - 1187
dc.titleT(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphorna that expresses nuclear BCL10
dc.typeJournal Article
rioxxterms.versionofrecord10.1182/blood.V98.4.1182
rioxxterms.licenseref.startdate2001-08-15en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBLOOD
pubs.notesunique-id: ISI:000170364100040
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume98en_US
pubs.embargo.termsNot known
dc.contributor.icrauthorHamoudi, Rifaten


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record