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dc.contributor.authorNahum, Aen_US
dc.date.accessioned2018-09-25T10:33:16Z
dc.date.issued2001-07en_US
dc.identifierhttp://publications.icr.ac.uk/299/en_US
dc.identifier.citationPHYSICS IN MEDICINE AND BIOLOGY, 2001, 46 (7), pp. 1815 - 1834en_US
dc.identifier.issn0031-9155en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2860
dc.description.abstractSeries model volume effects in a population of non-identical patients: how low is low? Working with several mechanisms of critical local tissue damage, formulae are analytically derived that describe normal tissue complication probabilities (ntcps) for series-type radiotherapy complications arising in heterogeneous patient populations. Using the formulae, values are calculated for DeltaD(5010)-the increase in dose leading to a 50% series-type complication rate (D-50) when irradiated organ volume is reduced tenfold. From the structure of the mcp formulae derived, it follows that dose-levels leading to clinically relevant serious complication rates (less than 5%) will change less with it-radiated volume than will D-50. Calculated values of DeltaD(5010) for the heterogeneous series model are low- generally less than 6 Gy; such values are much lower than those calculated for the non-heterogeneous series model (27-37 Gy). These results suggest that if the dose-limiting toxicity of a radiotherapy treatment is a series-type complication with a local damage mechanism similar to any of those studied in this work. then even very substantial improvements in technique- leading to large reductions in highly dosed normal tissue volumes-would be unlikely to allow a useful degree of escalation of the dose delivered to the tumour, unless highly dosed normal tissue volumes can be reduced below the length- scale of a functional subunit.en_US
dc.format.extent1815 - 1834en_US
dc.subjectGROWTH-FACTOR-BETA; CELLULAR RADIATION SENSITIVITY; NORMAL- TISSUE TOLERANCE; ENDOTHELIAL-CELLS; IN-VITRO; FIBROBLAST RADIOSENSITIVITY; EXTRACELLULAR-MATRIX; SKIN FIBROBLASTS; MAMMARY-GLAND; TGF-BETAen_US
dc.titleSeries model volume effects in a population of non-identical patients: how low is low?en_US
dc.typeJournal Article
rioxxterms.licenseref.startdate2001-07en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfPHYSICS IN MEDICINE AND BIOLOGYen_US
pubs.issue7en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume46en_US
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorFenwick, Jen_US


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