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Immunophenotype changes and loss of CD52 expression in two patients with relapsed T-cell prolymphocytic leukaemia

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ICR Author
Matutes, Estella
Author
Tuset, E
Matutes, E
Brito-Babapulle, V
Morilla, R
Catovsky, D
Type
Journal Article
Metadata
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Abstract
T-cell prolymphocytic leukaemia (T-PLL) is an aggressive disease often resistant to conventional chemotherapy. Long lasting remissions with the monoclonal antibody CAMPATH-1H (anti-CD52) have been documented. We describe two unusual T-PLL patients treated successfully first with CAMPATH-1H in whom, at the time of relapse, the cells underwent a phenotypic switch with loss of CD52 expression. In one of them, cytogenetic analysis demonstrated the same chromosome abnormalities in the cells at diagnosis and relapse. The reasons for the immunophenotypic changes are unknown but it is likely that loss of CD52 antigen expression contributed to the resistance to CAMPATH-1H in one of the patients when re-treated.
URI
https://repository.icr.ac.uk/handle/internal/2870
DOI
https://doi.org/10.3109/10428190109097766
Collections
  • Clinical Studies
  • Molecular Pathology
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
Date accepted
2009-07-01
License start date
2009-07-01
Citation
LEUKEMIA & LYMPHOMA, 42 pp. 1379 - 1383

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