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t(2;5) associated with a histiocytic-monocytic neoplasm

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Date
2001-04
ICR Author
Matutes, Estella
Author
Lemes, A
de la Iglesia, S
Santana, C
Cigudosa, JC
Matutes, E
Molero, T
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Type
Journal Article
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Abstract
We describe a patient with a neoplasm derived from the histiocytic-monocytic lineage associated with t(2:5) detected by FISH. The patient presented with bone marrow involvement, no organomegaly and subsequently developed a leukaemic picture. The clinical course was aggressive and the patient died four months from diagnosis. Cell morphology. immunophenotype (CD30-, EMA-, Lisozyme+, cy CD68+ and CD45+) and DNA analysis showing germ-line configuration of the Ig/TCR chain genes ruled out the diagnosis of anaplastic large cell lymphoma (ALCL). This unusual case ilustrates that t(2:5) is not exclusive for ALCL but may be found in a few cases of rare neoplasms derived from the histiocytic-monocytic cells.
URI
https://repository.icr.ac.uk/handle/internal/2872
DOI
https://doi.org/10.3109/10428190109058000
Collections
  • Clinical Studies
  • Molecular Pathology
Research team
Molecular Haematology (including Cytogenetics Group and Cell Markers)
Language
eng
License start date
2001-04
Citation
LEUKEMIA & LYMPHOMA, 2001, 41 pp. 429+ - 429+

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