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dc.contributor.authorMarzec, Jen_US
dc.contributor.authorMao, Xen_US
dc.contributor.authorLi, Men_US
dc.contributor.authorWang, Men_US
dc.contributor.authorFeng, Nen_US
dc.contributor.authorGou, Xen_US
dc.contributor.authorWang, Gen_US
dc.contributor.authorSun, Zen_US
dc.contributor.authorXu, Jen_US
dc.contributor.authorXu, Hen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorZhao, SCen_US
dc.contributor.authorRen, Gen_US
dc.contributor.authorYu, Yen_US
dc.contributor.authorWu, Yen_US
dc.contributor.authorWu, Jen_US
dc.contributor.authorXue, Yen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorXu, Xen_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorHe, Wen_US
dc.contributor.authorBenlloch, Sen_US
dc.contributor.authorRoss-Adams, Hen_US
dc.contributor.authorChen, Len_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorHong, Yen_US
dc.contributor.authorKote-Jarai, Zen_US
dc.contributor.authorCui, Xen_US
dc.contributor.authorHou, Jen_US
dc.contributor.authorGuo, Jen_US
dc.contributor.authorXu, Len_US
dc.contributor.authorYin, Cen_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorNeal, DEen_US
dc.contributor.authorOliver, Ten_US
dc.contributor.authorCao, Gen_US
dc.contributor.authorZhang, Zen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorChelala, Cen_US
dc.contributor.authorAl Olama, AAen_US
dc.contributor.authorEeles, RAen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorLu, YJen_US
dc.identifier.citationOncotarget, 2016, 7 (16), pp. 21393 - 21403en_US
dc.description.abstractProstate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the main contributors to Chinese prostate cancer risk and the risk alleles from three of them exist at much higher frequencies in Chinese than European populations. We also found that several predisposition loci reported in Western populations have different effect on Chinese men. Therefore, this first extensive single-nucleotide polymorphism study of Chinese prostate cancer in comparison with European population indicates that four loci on 8q24 contribute to a great risk of prostate cancer in a considerable large proportion of Chinese men. Based on those four loci, the top 10% of the population have six- or two-fold prostate cancer risk compared with men of the bottom 10% or median risk respectively, which may facilitate the design of prostate cancer genetic risk screening and prevention in Chinese men. These findings also provide additional insights into the etiology and pathogenesis of prostate cancer.en_US
dc.format.extent21393 - 21403en_US
dc.subjectPRACTICAL Consortiumen_US
dc.subjectCHIPGECS Groupen_US
dc.titleA genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.en_US
dc.typeJournal Article
rioxxterms.typeJournal Article/Reviewen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.embargo.termsNot knownen_US
dc.contributor.icrauthorEeles, Rosalinden_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen_US

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