Now showing items 133-152 of 369

    • Feasibility study of combined dynamic imaging and lymphaticovenous anastomosis surgery for breast cancer-related lymphoedema. 

      Khan, AA; Hernan, I; Adamthwaite, JA; Ramsey, KWD (2019-01)
      Background Breast cancer-related lymphoedema (BCRL) presents a significant healthcare burden and adversely affects quality of life of breast cancer survivors. A prospective feasibility study was performed on lymphaticovenous ...
    • FFPE breast tumour blocks provide reliable sources of both germline and malignant DNA for investigation of genetic determinants of individual tumour responses to treatment. 

      Wilkins, A; Chauhan, R; Rust, A; Pearson, A; Daley, F; Manodoro, F; Fenwick, K; Bliss, J; Yarnold, J; Somaiah, N (2018-08)
      Background Bio-banked formalin-fixed paraffin-embedded (FFPE) tissues provide an excellent opportunity for translational genomic research. Historically matched blood has not always been collected as a source of germline ...
    • Final analyses of OPTiM: a randomized phase III trial of talimogene laherparepvec versus granulocyte-macrophage colony-stimulating factor in unresectable stage III-IV melanoma. 

      Andtbacka, RHI; Collichio, F; Harrington, KJ; Middleton, MR; Downey, G; Ӧhrling, K; Kaufman, HL (2019-06-06)
      Background Talimogene laherparepvec is an oncolytic immunotherapy approved in the US, Europe, Australia and Switzerland. We report the final planned analysis of OPTiM, a randomized open-label phase III trial in patients ...
    • First report on the reliability and validity of speech handicap index in native English-speaking patients with head and neck cancer. 

      Dwivedi, RC; St Rose, S; Roe, JWG; Chisholm, E; Elmiyeh, B; Nutting, CM; Clarke, PM; Kerawala, CJ; Rhys-Evans, PH; Harrington, KJ; Kazi, R (2011-03)
      Background Posttreatment speech problems are seen in nearly half of patients with head and neck cancer. Although there are many voice-specific scales, surprisingly there is no speech-specific questionnaire for English-speaking ...
    • Flexible Data Analysis Pipeline for High-Confidence Proteogenomics. 

      Weisser, H; Wright, JC; Mudge, JM; Gutenbrunner, P; Choudhary, JS (2016-12)
      Proteogenomics leverages information derived from proteomic data to improve genome annotations. Of particular interest are "novel" peptides that provide direct evidence of protein expression for genomic regions not previously ...
    • Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study 

      Fendler, A; Au, L; Shepherd, STC; Byrne, F; Cerrone, M; Boos, LA; Rzeniewicz, K; Gordon, W; Shum, B; Gerard, CL; Ward, B; Xie, W; Schmitt, AM; Joharatnam-Hogan, N; Cornish, GH; Pule, M; Mekkaoui, L; Ng, KW; Carlyle, E; Edmonds, K; Rosario, LD; Sarker, S; Lingard, K; Mangwende, M; Holt, L; Ahmod, H; Stone, R; Gomes, C; Flynn, HR; Agua-Doce, A; Hobson, P; Caidan, S; Howell, M; Wu, M; Goldstone, R; Crawford, M; Cubitt, L; Patel, H; Gavrielides, M; Nye, E; Snijders, AP; MacRae, JI; Nicod, J; Gronthoud, F; Shea, RL; Messiou, C; Cunningham, D; Chau, I; Starling, N; Turner, N; Welsh, L; van As, N; Jones, RL; Droney, J; Banerjee, S; Tatham, KC; Jhanji, S; O’Brien, M; Curtis, O; Harrington, K; Bhide, S; Bazin, J; Robinson, A; Stephenson, C; Slattery, T; Khan, Y; Tippu, Z; Leslie, I; Gennatas, S; Okines, A; Reid, A; Young, K; Furness, AJS; Pickering, L; Gandhi, S; Gamblin, S; Swanton, C; Nicholson, E; Kumar, S; Yousaf, N; Wilkinson, KA; Swerdlow, A; Harvey, R; Kassiotis, G; Larkin, J; Wilkinson, RJ; Turajlic, S
      <jats:title>Abstract</jats:title><jats:p>Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. ...
    • Functional coupling of transcription and splicing 

      Sanchez Alvarez, Miguel (2012-06)
      The tightly regulated process of precursor messenger RNA (pre-mRNA) alternative splicing is a key mechanism to increase the number and complexity of proteins encoded by the genome. Evidence gathered in recent years has ...
    • Functional Data Analysis Applied to Modeling of Severe Acute Mucositis and Dysphagia Resulting From Head and Neck Radiation Therapy. 

      Dean, JA; Wong, KH; Gay, H; Welsh, LC; Jones, A-B; Schick, U; Oh, JH; Apte, A; Newbold, KL; Bhide, SA; Harrington, KJ; Deasy, JO; Nutting, CM; Gulliford, SL (2016-11)
      Purpose Current normal tissue complication probability modeling using logistic regression suffers from bias and high uncertainty in the presence of highly correlated radiation therapy (RT) dose data. This hinders robust ...
    • GENCODE reference annotation for the human and mouse genomes. 

      Frankish, A; Diekhans, M; Ferreira, A-M; Johnson, R; Jungreis, I; Loveland, J; Mudge, JM; Sisu, C; Wright, J; Armstrong, J; Barnes, I; Berry, A; Bignell, A; Carbonell Sala, S; Chrast, J; Cunningham, F; Di Domenico, T; Donaldson, S; Fiddes, IT; García Girón, C; Gonzalez, JM; Grego, T; Hardy, M; Hourlier, T; Hunt, T; Izuogu, OG; Lagarde, J; Martin, FJ; Martínez, L; Mohanan, S; Muir, P; Navarro, FCP; Parker, A; Pei, B; Pozo, F; Ruffier, M; Schmitt, BM; Stapleton, E; Suner, M-M; Sycheva, I; Uszczynska-Ratajczak, B; Xu, J; Yates, A; Zerbino, D; Zhang, Y; Aken, B; Choudhary, JS; Gerstein, M; Guigó, R; Hubbard, TJP; Kellis, M; Paten, B; Reymond, A; Tress, ML; Flicek, P (2019-01)
      The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 ...
    • Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues. 

      Khan, AA; Paget, JT; McLaughlin, M; Kyula, JN; Wilkinson, MJ; Pencavel, T; Mansfield, D; Roulstone, V; Seth, R; Halle, M; Somaiah, N; Boult, JKR; Robinson, SP; Pandha, HS; Vile, RG; Melcher, AA; Harris, PA; Harrington, KJ (2018-01)
      Improvements in cancer survival mean that long-term toxicities, which contribute to the morbidity of cancer survivorship, are being increasingly recognized. Late adverse effects (LAEs) in normal tissues after radiotherapy ...
    • Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. 

      Pettitt, SJ; Krastev, DB; Brandsma, I; Dréan, A; Song, F; Aleksandrov, R; Harrell, MI; Menon, M; Brough, R; Campbell, J; Frankum, J; Ranes, M; Pemberton, HN; Rafiq, R; Fenwick, K; Swain, A; Guettler, S; Lee, J-M; Swisher, EM; Stoynov, S; Yusa, K; Ashworth, A; Lord, CJ (2018-05-10)
      Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density CRISPR-Cas9 ...
    • Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. 

      Pettitt, SJ; Krastev, DB; Pemberton, HN; Fontebasso, Y; Frankum, J; Rehman, FL; Brough, R; Song, F; Bajrami, I; Rafiq, R; Wallberg, F; Kozarewa, I; Fenwick, K; Armisen-Garrido, J; Swain, A; Gulati, A; Campbell, J; Ashworth, A; Lord, CJ (2017-03)
      We describe a screen for cellular response to drugs that makes use of haploid embryonic stem cells. We generated ten libraries of mutants with piggyBac gene trap transposon integrations, totalling approximately 100,000 ...
    • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells. 

      Roumeliotis, TI; Williams, SP; Gonçalves, E; Alsinet, C; Del Castillo Velasco-Herrera, M; Aben, N; Ghavidel, FZ; Michaut, M; Schubert, M; Price, S; Wright, JC; Yu, L; Yang, M; Dienstmann, R; Guinney, J; Beltrao, P; Brazma, A; Pardo, M; Stegle, O; Adams, DJ; Wessels, L; Saez-Rodriguez, J; McDermott, U; Choudhary, JS (2017-08)
      Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 ...
    • Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study. 

      Grünwald, V; Chirovsky, D; Cheung, WY; Bertolini, F; Ahn, M-J; Yang, M-H; Castro, G; Berrocal, A; Sjoquist, K; Kuyas, H; Auclair, V; Guillaume, X; Joo, S; Shah, R; Harrington, K; GLANCE H&N STUDY Investigators (2020-03)
      OBJECTIVES:Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and ...
    • Gustatory function following radiotherapy to the head and neck 

      Gunn, L (2021-11-30)
      An intact sense of taste provides pleasure, supports sustenance and alerts the body to potential toxins. Patients with head and neck (HNC) who undergo radiotherapy (RT) are at high risk of developing acute and late taste ...
    • HER3-Mediated Resistance to Hsp90 Inhibition Detected in Breast Cancer Xenografts by Affibody-Based PET Imaging. 

      Martins, CD; Da Pieve, C; Burley, TA; Smith, R; Ciobota, DM; Allott, L; Harrington, KJ; Oyen, WJG; Smith, G; Kramer-Marek, G (2018-04)
      Purpose: Recent studies have highlighted a role of HER3 in HER2-driven cancers (e.g., breast cancer), implicating the upregulation of the receptor in resistance to HER-targeted therapies and Hsp90 inhibitors (e.g., AUY922). ...
    • High-Level Clonal FGFR Amplification and Response to FGFR Inhibition in a Translational Clinical Trial. 

      Pearson, A; Smyth, E; Babina, IS; Herrera-Abreu, MT; Tarazona, N; Peckitt, C; Kilgour, E; Smith, NR; Geh, C; Rooney, C; Cutts, R; Campbell, J; Ning, J; Fenwick, K; Swain, A; Brown, G; Chua, S; Thomas, A; Johnston, SRD; Ajaz, M; Sumpter, K; Gillbanks, A; Watkins, D; Chau, I; Popat, S; Cunningham, D; Turner, NC (2016-08)
      Unlabelled FGFR1 and FGFR2 are amplified in many tumor types, yet what determines response to FGFR inhibition in amplified cancers is unknown. In a translational clinical trial, we show that gastric cancers with high-level ...
    • Histone isoforms and the oncohistone code. 

      Flaus, A; Downs, JA; Owen-Hughes, T (2020-12-04)
      Recent studies have highlighted the potential for missense mutations in histones to act as oncogenic drivers, leading to the term 'oncohistones'. While histone proteins are highly conserved, they are encoded by multigene ...
    • How RhoGEFs drive triple negative breast cancer cell invasion through the activation of YAP and TAZ 

      Pascual Vargas, P (2020-03-31)
      Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis (TNBC). Cell shape is regulated by RhoGEFs which activate Rho GTPases resulting in changes in actin polymerisation, ...
    • HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours. 

      Francis, JC; Gardiner, JR; Renaud, Y; Chauhan, R; Weinstein, Y; Gomez-Sanchez, C; Lefrançois-Martinez, A-M; Bertherat, J; Val, P; Swain, A (2020-11-20)
      Background Understanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and other HOX ...