Now showing items 1-2 of 2

    • Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis. 

      Hill, C; Li, J; Liu, D; Conforti, F; Brereton, CJ; Yao, L; Zhou, Y; Alzetani, A; Chee, SJ; Marshall, BG; Fletcher, SV; Hancock, D; Ottensmeier, CH; Steele, AJ; Downward, J; Richeldi, L; Lu, X; Davies, DE; Jones, MG; Wang, Y (2019-08-07)
      Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries to an ageing, susceptible alveolar epithelium. Ageing is a ...
    • Tumour-suppression function of KLF12 through regulation of anoikis. 

      Godin-Heymann, N; Brabetz, S; Murillo, MM; Saponaro, M; Santos, CR; Lobley, A; East, P; Chakravarty, P; Matthews, N; Kelly, G; Jordan, S; Castellano, E; Downward, J (2016-06)
      Suppression of detachment-induced cell death, known as anoikis, is an essential step for cancer metastasis to occur. We report here that expression of KLF12, a member of the Kruppel-like family of transcription factors, ...