Now showing items 1-2 of 2

    • Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination. 

      Liess, AKL; Kucerova, A; Schweimer, K; Yu, L; Roumeliotis, TI; Diebold, M; Dybkov, O; Sotriffer, C; Urlaub, H; Choudhary, JS; Mansfeld, J; Lorenz, S (2019-08)
      Ubiquitin-conjugating enzymes (E2s) govern key aspects of ubiquitin signaling. Emerging evidence suggests that the activities of E2s are modulated by posttranslational modifications; the structural underpinnings, however, ...
    • Structural basis for the inhibition of cGAS by nucleosomes. 

      Kujirai, T; Zierhut, C; Takizawa, Y; Kim, R; Negishi, L; Uruma, N; Hirai, S; Funabiki, H; Kurumizaka, H (2020-10)
      The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and apoptosis. Organization of host DNA into nucleosomes was ...