Now showing items 1-6 of 6

    • An orally bioavailable Chk1 inhibitor, CCT244747, sensitizes bladder and head and neck cancer cell lines to radiation. 

      Patel, R; Barker, HE; Kyula, J; McLaughlin, M; Dillon, MT; Schick, U; Hafsi, H; Thompson, A; Khoo, V; Harrington, K; Zaidi, S (2017-03)
      Purpose Chk1 inhibition increases cell sensitivity to both chemotherapy and radiotherapy in several tumour types and is, therefore, a promising anti-cancer approach. Although several Chk1 inhibitors have been developed, ...
    • Perspectives on ENCODE. 

      ENCODE Project Consortium; Snyder, MP; Gingeras, TR; Moore, JE; Weng, Z; Gerstein, MB; Ren, B; Hardison, RC; Stamatoyannopoulos, JA; Graveley, BR; Feingold, EA; Pazin, MJ; Pagan, M; Gilchrist, DA; Hitz, BC; Cherry, JM; Bernstein, BE; Mendenhall, EM; Zerbino, DR; Frankish, A; Flicek, P; Myers, RM (2020-07-29)
      The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated ...
    • Removal of H2A.Z by INO80 promotes homologous recombination. 

      Alatwi, HE; Downs, JA (2015-08)
      The mammalian INO80 remodelling complex facilitates homologous recombination (HR), but the mechanism by which it does this is unclear. Budding yeast INO80 can remove H2A.Z/H2B dimers from chromatin and replace them with ...
    • Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. 

      Kakarougkas, A; Ismail, A; Chambers, AL; Riballo, E; Herbert, AD; Künzel, J; Löbrich, M; Jeggo, PA; Downs, JA (2014-09)
      Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not known ...
    • The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. 

      Zhang, W; Chronis, C; Chen, X; Zhang, H; Spalinskas, R; Pardo, M; Chen, L; Wu, G; Zhu, Z; Yu, Y; Yu, L; Choudhary, J; Nichols, J; Parast, MM; Greber, B; Sahlén, P; Plath, K (2019-01)
      BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ...
    • UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs. 

      Gozdecka, M; Meduri, E; Mazan, M; Tzelepis, K; Dudek, M; Knights, AJ; Pardo, M; Yu, L; Choudhary, JS; Metzakopian, E; Iyer, V; Yun, H; Park, N; Varela, I; Bautista, R; Collord, G; Dovey, O; Garyfallos, DA; De Braekeleer, E; Kondo, S; Cooper, J; Göttgens, B; Bullinger, L; Northcott, PA; Adams, D; Vassiliou, GS; Huntly, BJP (2018-06)
      The histone H3 Lys27-specific demethylase UTX (or KDM6A) is targeted by loss-of-function mutations in multiple cancers. Here, we demonstrate that UTX suppresses myeloid leukemogenesis through noncatalytic functions, a ...