Now showing items 1-3 of 3

    • APOBEC3B-mediated corruption of the tumor cell immunopeptidome induces heteroclitic neoepitopes for cancer immunotherapy. 

      Driscoll, CB; Schuelke, MR; Kottke, T; Thompson, JM; Wongthida, P; Tonne, JM; Huff, AL; Miller, A; Shim, KG; Molan, A; Wetmore, C; Selby, P; Samson, A; Harrington, K; Pandha, H; Melcher, A; Pulido, JS; Harris, R; Evgin, L; Vile, RG (2020-02-07)
      APOBEC3B, an anti-viral cytidine deaminase which induces DNA mutations, has been implicated as a mediator of cancer evolution and therapeutic resistance. Mutational plasticity also drives generation of neoepitopes, which ...
    • Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition. 

      Jennings, VA; Scott, GB; Rose, AMS; Scott, KJ; Migneco, G; Keller, B; Reilly, K; Donnelly, O; Peach, H; Dewar, D; Harrington, KJ; Pandha, H; Samson, A; Vile, RG; Melcher, AA; Errington-Mais, F (2019-06)
      A clinical oncolytic herpes simplex virus (HSV) encoding granulocyte-macrophage colony-stimulating factor (GM-CSF), talimogene laherparepvec, causes regression of injected and non-injected melanoma lesions in patients and ...
    • Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence. 

      Kottke, T; Evgin, L; Shim, KG; Rommelfanger, D; Boisgerault, N; Zaidi, S; Diaz, RM; Thompson, J; Ilett, E; Coffey, M; Selby, P; Pandha, H; Harrington, K; Melcher, A; Vile, R (2017-11)
      Understanding how incompletely cleared primary tumors transition from minimal residual disease (MRD) into treatment-resistant, immune-invisible recurrences has major clinical significance. We show here that this transition ...