Now showing items 1-2 of 2

    • CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks. 

      Rother, MB; Pellegrino, S; Smith, R; Gatti, M; Meisenberg, C; Wiegant, WW; Luijsterburg, MS; Imhof, R; Downs, JA; Vertegaal, ACO; Huet, S; Altmeyer, M; van Attikum, H (2020-11-13)
      Chromatin structure is dynamically reorganized at multiple levels in response to DNA double-strand breaks (DSBs). Yet, how the different steps of chromatin reorganization are coordinated in space and time to differentially ...
    • Direct involvement of retinoblastoma family proteins in DNA repair by non-homologous end-joining. 

      Cook, R; Zoumpoulidou, G; Luczynski, MT; Rieger, S; Moquet, J; Spanswick, VJ; Hartley, JA; Rothkamm, K; Huang, PH; Mittnacht, S (2015-03-26)
      Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA ...