Show simple item record

dc.contributor.authorFassan, M
dc.contributor.authorCui, R
dc.contributor.authorGasparini, P
dc.contributor.authorMescoli, C
dc.contributor.authorGuzzardo, V
dc.contributor.authorVicentini, C
dc.contributor.authorMunari, G
dc.contributor.authorLoupakis, F
dc.contributor.authorLonardi, S
dc.contributor.authorBraconi, C
dc.contributor.authorScarpa, M
dc.contributor.authorD'Angelo, E
dc.contributor.authorPucciarelli, S
dc.contributor.authorAngriman, I
dc.contributor.authorAgostini, M
dc.contributor.authorD'Incá, R
dc.contributor.authorFarinati, F
dc.contributor.authorGafà, R
dc.contributor.authorLanza, G
dc.contributor.authorFrankel, WL
dc.contributor.authorCroce, CM
dc.contributor.authorValeri, N
dc.contributor.authorRugge, M
dc.date.accessioned2019-04-18T08:43:10Z
dc.date.issued2019-02
dc.identifier.citationTranslational oncology, 2019, 12 (2), pp. 282 - 291
dc.identifier.issn1936-5233
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3192
dc.identifier.eissn1936-5233
dc.identifier.doi10.1016/j.tranon.2018.10.013
dc.description.abstractmiR-224 has recently emerged as a driver oncomiR in sporadic colorectal carcinogenesis, but its pathogenetic role is still controversial. A large phenotypical and molecularly characterized series of preinvasive and invasive colorectal lesions was investigated for miR-224 expression by qRT-PCR and in situ hybridization. The caspase-3 and caspase-7 status was also assessed and correlated to miR-224 dysregulation. miR-224 was significantly upregulated during the adenoma-carcinoma sequence and in the context of inflammatory bowel disease dysplastic lesions, whereas its expression was significantly downregulated among BRAF-mutated tumors and in the presence of a DNA mismatch repair deficiency. miR-224 targets caspase-3 and caspase-7 in colorectal cancer, and this inverse relation was already evident from the earliest phases of transformation in intestinal mucosa. The miR-224/caspases axis may represent an interesting field of study for innovative biomarkers/therapeutics for BRAF-mutated/DNA mismatch repair-deficient tumors.
dc.formatPrint-Electronic
dc.format.extent282 - 291
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titlemiR-224 Is Significantly Upregulated and Targets Caspase-3 and Caspase-7 During Colorectal Carcinogenesis.
dc.typeJournal Article
dcterms.dateAccepted2018-10-31
rioxxterms.versionofrecord10.1016/j.tranon.2018.10.013
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0
rioxxterms.licenseref.startdate2019-02
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfTranslational oncology
pubs.issue2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Therapeutics/Signal Transduction & Molecular Pharmacology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gastrointestinal Cancer Biology and Genomics
pubs.publication-statusPublished
pubs.volume12
pubs.embargo.termsNot known
icr.researchteamSignal Transduction & Molecular Pharmacologyen_US
icr.researchteamGastrointestinal Cancer Biology and Genomicsen_US
dc.contributor.icrauthorBraconi, Chiaraen
dc.contributor.icrauthorValeri, Nicolaen


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

https://creativecommons.org/licenses/by/4.0
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0