dc.contributor.author | Giles, SL | |
dc.contributor.author | Imseeh, G | |
dc.contributor.author | Rivens, I | |
dc.contributor.author | Ter Haar, GR | |
dc.contributor.author | Taylor, A | |
dc.contributor.author | deSouza, NM | |
dc.date.accessioned | 2019-05-16T15:21:59Z | |
dc.date.issued | 2019-05-16 | |
dc.identifier.citation | The British journal of radiology, 2019, 92 (1098), pp. 20181037 - ? | |
dc.identifier.issn | 0007-1285 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3230 | |
dc.identifier.eissn | 1748-880X | |
dc.identifier.doi | 10.1259/bjr.20181037 | |
dc.description.abstract | OBJECTIVE: To assess the feasibility of targeting recurrent gynaecological tumours with MR guided high intensity focused ultrasound (MRgHIFU). METHODS: 20 patients with recurrent gynaecological tumours were prospectively scanned on a Philips/Profound 3 T Achieva MR/ Sonalleve HIFU system. Gross tumour volume (GTV) and planning target volume (PTV) were delineated on T 2W and diffusion-weighted imaging (DWI). Achievable treatment volumes that (i) assumed bowel and/or urogenital tract preparation could be used to reduce risk of damage to organs-at-risk (TVoptimal), or (ii) assumed no preparations were possible (TVno-prep) were compared with PTV on virtual treatment plans. Patients were considered treatable if TVoptimal ≥ 50 % PTV. RESULTS: 11/20 patients (55%) were treatable if preparation strategies were used: nine had central pelvic recurrences, two had tumours in metastatic locations. Treatable volume ranged from 3.4 to 90.3 ml, representing 70 ± 17 % of PTVs. Without preparation, 6/20 (30%) patients were treatable (four central recurrences, two metastatic lesions). Limiting factors were disease beyond reach of the HIFU transducer, and bone obstructing tumour access. DWI assisted tumour outlining, but differences from T 2W imaging in GTV size (16.9 ± 23.0%) and PTV location (3.8 ± 2.8 mm in phase-encode direction) limited its use for treatment planning. CONCLUSIONS: Despite variation in size and location within the pelvis, ≥ 50 % of tumour volumes were considered targetable in 55 % patients while avoiding adjacent critical structures. A prospective treatment study will assess safety and symptom relief in a second patient cohort. ADVANCES IN KNOWLEDGE: Target size, location and access make MRgHIFU a viable treatment modality for treating symptomatic recurrent gynaecological tumours within the pelvis. | |
dc.format | Print-Electronic | |
dc.format.extent | 20181037 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BRITISH INST RADIOLOGY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Genital Neoplasms, Female | |
dc.subject | Neoplasm Recurrence, Local | |
dc.subject | Tumor Burden | |
dc.subject | Prospective Studies | |
dc.subject | Feasibility Studies | |
dc.subject | Pilot Projects | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Magnetic Resonance Imaging, Interventional | |
dc.subject | Patient Positioning | |
dc.subject | High-Intensity Focused Ultrasound Ablation | |
dc.title | MR guided high intensity focused ultrasound (MRgHIFU) for treating recurrent gynaecological tumours: a pilot feasibility study. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2019-04-01 | |
rioxxterms.versionofrecord | 10.1259/bjr.20181037 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-06 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | The British journal of radiology | |
pubs.issue | 1098 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Therapeutic Ultrasound | |
pubs.publication-status | Published | |
pubs.volume | 92 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Magnetic Resonance | |
icr.researchteam | Therapeutic Ultrasound | |
dc.contributor.icrauthor | Rivens, Ian | |
dc.contributor.icrauthor | Ter Haar, Gail | |
dc.contributor.icrauthor | deSouza, Nandita | |