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dc.contributor.authorSud, Aen_US
dc.contributor.authorChattopadhyay, Sen_US
dc.contributor.authorThomsen, Hen_US
dc.contributor.authorSundquist, Ken_US
dc.contributor.authorSundquist, Jen_US
dc.contributor.authorHoulston, RSen_US
dc.contributor.authorHemminki, Ken_US
dc.coverage.spatialUnited Statesen_US
dc.date.accessioned2019-06-27T09:25:13Z
dc.date.issued2019-08-08en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/31395603en_US
dc.identifierblood.2019001362en_US
dc.identifier.citationBlood, 2019en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3277
dc.identifier.eissn1528-0020en_US
dc.identifier.doi10.1182/blood.2019001362en_US
dc.description.abstractEstimating familial cancer risks is clinically important in being able to discriminate between individuals in the population at differing risk of malignancy. To gain insight into the familial risk of the different hematological malignancies and their possible inter-relationship, we analyzed data on over 16 million individuals from the Swedish Family-Cancer Database. After identifying 153,115 patients diagnosed with a primary hematological malignancy, we quantified familial relative risks (FRRs) by calculating standardized incident ratios (SIR) in their 391,131 first-degree relatives. The majority of hematological malignancies showed increased FRRs for the same tumor type, with the highest FRRs being observed for mixed cellularity Hodgkin lymphoma (SIR=16.7), lymphoplasmacytic lymphoma (SIR=15.8) and mantle cell lymphoma (SIR=13.3). There was evidence for pleiotropic relationships, notably chronic lymphocytic leukemia (CLL) was associated with an elevated familial risk of other B-cell tumors and myeloproliferative neoplasms. Collectively these data provide evidence for shared etiological factors for many hematological malignancies and provide information for identifying individuals at increased risk as well as informing future gene discovery initiatives.en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleAnalysis of 153,115 patients with hematological malignancies refines the spectrum of familial risk.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-06-26en_US
rioxxterms.versionofrecord10.1182/blood.2019001362en_US
rioxxterms.licenseref.startdate2019-08-08en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBlooden_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.publication-statusPublished onlineen_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorSud, Amiten_US


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/