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dc.contributor.authorGurney-Champion, OJ
dc.contributor.authorRauh, SS
dc.contributor.authorHarrington, K
dc.contributor.authorOelfke, U
dc.contributor.authorLaun, FB
dc.contributor.authorWetscherek, A
dc.date.accessioned2019-10-01T09:15:57Z
dc.date.issued2020-03
dc.identifier.citationMagnetic resonance in medicine, 2020, 83 (3), pp. 1003 - 1015
dc.identifier.issn0740-3194
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3372
dc.identifier.eissn1522-2594
dc.identifier.doi10.1002/mrm.27990
dc.description.abstractPurpose Flow-compensated (FC) diffusion-weighted MRI (DWI) for intravoxel-incoherent motion (IVIM) modeling allows for a more detailed description of tissue microvasculature than conventional IVIM. The long acquisition time of current FC-IVIM protocols, however, has prohibited clinical application. Therefore, we developed an optimized abdominal FC-IVIM acquisition with a clinically feasible scan time.Methods Precision and accuracy of the FC-IVIM parameters were assessed by fitting the FC-IVIM model to signal decay curves, simulated for different acquisition schemes. Diffusion-weighted acquisitions were added subsequently to the protocol, where we chose the combination of b-value, diffusion time and gradient profile (FC or bipolar) that resulted in the largest improvement to its accuracy and precision. The resulting two optimized FC-IVIM protocols with 25 and 50 acquisitions (FC-IVIM opt25 and FC-IVIM opt50 ), together with a complementary acquisition consisting of 50 diffusion-weighting (FC-IVIM comp ), were acquired in repeated abdominal free-breathing FC-IVIM imaging of seven healthy volunteers. Intersession and intrasession within-subject coefficient of variation of the FC-IVIM parameters were compared for the liver, spleen, and kidneys.Results Simulations showed that the performance of FC-IVIM improved in tissue with larger perfusion fraction and signal-to-noise ratio. The scan time of the FC-IVIM opt25 and FC-IVIM opt50 protocols were 8 and 16 min. The best in vivo performance was seen in FC-IVIM opt50 . The intersession within-subject coefficients of variation of FC-IVIM opt50 were 11.6%, 16.3%, 65.5%, and 36.0% for FC-IVIM model parameters diffusivity, perfusion fraction, characteristic time and blood flow velocity, respectively.Conclusions We have optimized the FC-IVIM protocol, allowing for clinically feasible scan times (8-16 min).
dc.formatPrint-Electronic
dc.format.extent1003 - 1015
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleOptimal acquisition scheme for flow-compensated intravoxel incoherent motion diffusion-weighted imaging in the abdomen: An accurate and precise clinically feasible protocol.
dc.typeJournal Article
dcterms.dateAccepted2019-08-17
rioxxterms.versionofrecord10.1002/mrm.27990
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-03
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfMagnetic resonance in medicine
pubs.issue3
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.publication-statusPublished
pubs.volume83
pubs.embargo.termsNo embargo
icr.researchteamRadiotherapy Physics Modellingen_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorGurney-Champion, Oliveren
dc.contributor.icrauthorOelfke, Uween
dc.contributor.icrauthorHarrington, Kevinen
dc.contributor.icrauthorWetscherek, Andreasen


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