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dc.contributor.authorWilliams, MJ
dc.contributor.authorSottoriva, A
dc.contributor.authorGraham, TA
dc.date.accessioned2020-01-24T10:55:37Z
dc.date.issued2019-08
dc.identifier.citationAnnual review of genomics and human genetics, 2019, 20 pp. 309 - 329
dc.identifier.issn1527-8204
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3494
dc.identifier.eissn1545-293X
dc.identifier.doi10.1146/annurev-genom-083117-021712
dc.description.abstractCancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal cell number. Viewed through the lens of evolutionary biology, the transformation of normal cells into malignant cells is evolution in action. Evolution continues throughout cancer growth, progression, treatment resistance, and disease relapse, driven by adaptation to changes in the cancer's environment, and intratumor heterogeneity is an inevitable consequence of this evolutionary process. Genomics provides a powerful means to characterize tumor evolution, enabling quantitative measurement of evolving clones across space and time. In this review, we discuss concepts and approaches to quantify and measure this evolutionary process in cancer using genomics.
dc.formatPrint-Electronic
dc.format.extent309 - 329
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectSequence Analysis, DNA
dc.subjectGenomics
dc.subjectMutation
dc.subjectModels, Genetic
dc.subjectHigh-Throughput Nucleotide Sequencing
dc.subjectClonal Evolution
dc.titleMeasuring Clonal Evolution in Cancer with Genomics.
dc.typeJournal Article
dcterms.dateAccepted2019-05-06
rioxxterms.versionofrecord10.1146/annurev-genom-083117-021712
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/under-embargo-all-rights-reserved
rioxxterms.licenseref.startdate2019-08
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfAnnual review of genomics and human genetics
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.publication-statusPublished
pubs.volume20
pubs.embargo.termsNot known
dc.contributor.icrauthorSottoriva, Andreaen


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