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dc.contributor.authorHarrison, PTen_US
dc.contributor.authorVyse, Sen_US
dc.contributor.authorHuang, PHen_US
dc.date.accessioned2020-05-22T11:15:04Z
dc.date.issued2020-04en_US
dc.identifier.citationSeminars in cancer biology, 2020, 61 pp. 167 - 179en_US
dc.identifier.issn1044-579Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3623
dc.identifier.eissn1096-3650en_US
dc.identifier.doi10.1016/j.semcancer.2019.09.015en_US
dc.description.abstractEpidermal growth factor receptor (EGFR) mutations are the second most common oncogenic driver event in non-small cell lung cancer (NSCLC). Classical activating mutations (exon 19 deletions and the L858R point mutation) comprise the vast majority of EGFR mutations and are well defined as strong predictors for good clinical response to EGFR tyrosine kinase inhibitors (EGFRi). However, low frequency mutations including point mutations, deletions, insertions and duplications occur within exons 18-25 of the EGFR gene in NSCLC and are associated with poorer responses to EGFRi. Despite an increased uptake of more sensitive detection methods to identify rare EGFR mutations in patients, our understanding of the biology of these rare EGFR mutations is poor compared to classical mutations. In particular, clinical data focused on these mutations is lacking due to their rarity and challenges in trial recruitment, resulting in an absence of effective treatment strategies for many low frequency EGFR mutations. In this review, we describe the structural and mechanistic features of rare EGFR mutations in NSCLC and discuss the preclinical and clinical evidence for EGFRi response for individual rare EGFR mutations. We also discuss EGFRi sensitivity for complex EGFR mutations, and conclude by offering a perspective on the outstanding questions and future steps required to make advances in the treatment of NSCLC patients that harbour rare EGFR mutations.en_US
dc.formatPrint-Electronicen_US
dc.format.extent167 - 179en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleRare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer.en_US
dc.typeJournal Article
dcterms.dateAccepted2019-09-20en_US
rioxxterms.versionofrecord10.1016/j.semcancer.2019.09.015en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2020-04en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfSeminars in cancer biologyen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular and Systems Oncology
pubs.publication-statusPublisheden_US
pubs.volume61en_US
pubs.embargo.termsNot knownen_US
icr.researchteamMolecular and Systems Oncologyen_US
dc.contributor.icrauthorHuang, Paulen_US
dc.contributor.icrauthorHarrison, Peteren_US


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