dc.contributor.author | Millstein, J | |
dc.contributor.author | Budden, T | |
dc.contributor.author | Goode, EL | |
dc.contributor.author | Anglesio, MS | |
dc.contributor.author | Talhouk, A | |
dc.contributor.author | Intermaggio, MP | |
dc.contributor.author | Leong, HS | |
dc.contributor.author | Chen, S | |
dc.contributor.author | Elatre, W | |
dc.contributor.author | Gilks, B | |
dc.contributor.author | Nazeran, T | |
dc.contributor.author | Volchek, M | |
dc.contributor.author | Bentley, RC | |
dc.contributor.author | Wang, C | |
dc.contributor.author | Chiu, DS | |
dc.contributor.author | Kommoss, S | |
dc.contributor.author | Leung, SCY | |
dc.contributor.author | Senz, J | |
dc.contributor.author | Lum, A | |
dc.contributor.author | Chow, V | |
dc.contributor.author | Sudderuddin, H | |
dc.contributor.author | Mackenzie, R | |
dc.contributor.author | George, J | |
dc.contributor.author | AOCS Group, | |
dc.contributor.author | Fereday, S | |
dc.contributor.author | Hendley, J | |
dc.contributor.author | Traficante, N | |
dc.contributor.author | Steed, H | |
dc.contributor.author | Koziak, JM | |
dc.contributor.author | Köbel, M | |
dc.contributor.author | McNeish, IA | |
dc.contributor.author | Goranova, T | |
dc.contributor.author | Ennis, D | |
dc.contributor.author | Macintyre, G | |
dc.contributor.author | Silva De Silva, D | |
dc.contributor.author | Ramón Y Cajal, T | |
dc.contributor.author | García-Donas, J | |
dc.contributor.author | Hernando Polo, S | |
dc.contributor.author | Rodriguez, GC | |
dc.contributor.author | Cushing-Haugen, KL | |
dc.contributor.author | Harris, HR | |
dc.contributor.author | Greene, CS | |
dc.contributor.author | Zelaya, RA | |
dc.contributor.author | Behrens, S | |
dc.contributor.author | Fortner, RT | |
dc.contributor.author | Sinn, P | |
dc.contributor.author | Herpel, E | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Oszurek, O | |
dc.contributor.author | Tołoczko, A | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Menkiszak, J | |
dc.contributor.author | Pearce, CL | |
dc.contributor.author | Pike, MC | |
dc.contributor.author | Tseng, C | |
dc.contributor.author | Alsop, J | |
dc.contributor.author | Rhenius, V | |
dc.contributor.author | Song, H | |
dc.contributor.author | Jimenez-Linan, M | |
dc.contributor.author | Piskorz, AM | |
dc.contributor.author | Gentry-Maharaj, A | |
dc.contributor.author | Karpinskyj, C | |
dc.contributor.author | Widschwendter, M | |
dc.contributor.author | Singh, N | |
dc.contributor.author | Kennedy, CJ | |
dc.contributor.author | Sharma, R | |
dc.contributor.author | Harnett, PR | |
dc.contributor.author | Gao, B | |
dc.contributor.author | Johnatty, SE | |
dc.contributor.author | Sayer, R | |
dc.contributor.author | Boros, J | |
dc.contributor.author | Winham, SJ | |
dc.contributor.author | Keeney, GL | |
dc.contributor.author | Kaufmann, SH | |
dc.contributor.author | Larson, MC | |
dc.contributor.author | Luk, H | |
dc.contributor.author | Hernandez, BY | |
dc.contributor.author | Thompson, PJ | |
dc.contributor.author | Wilkens, LR | |
dc.contributor.author | Carney, ME | |
dc.contributor.author | Trabert, B | |
dc.contributor.author | Lissowska, J | |
dc.contributor.author | Brinton, L | |
dc.contributor.author | Sherman, ME | |
dc.contributor.author | Bodelon, C | |
dc.contributor.author | Hinsley, S | |
dc.contributor.author | Lewsley, LA | |
dc.contributor.author | Glasspool, R | |
dc.contributor.author | Banerjee, SN | |
dc.contributor.author | Stronach, EA | |
dc.contributor.author | Haluska, P | |
dc.contributor.author | Ray-Coquard, I | |
dc.contributor.author | Mahner, S | |
dc.contributor.author | Winterhoff, B | |
dc.contributor.author | Slamon, D | |
dc.contributor.author | Levine, DA | |
dc.contributor.author | Kelemen, LE | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Gronwald, J | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Menon, U | |
dc.contributor.author | Goodman, MT | |
dc.contributor.author | Schildkraut, JM | |
dc.contributor.author | Wentzensen, N | |
dc.contributor.author | Brown, R | |
dc.contributor.author | Berchuck, A | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | deFazio, A | |
dc.contributor.author | Gayther, SA | |
dc.contributor.author | García, MJ | |
dc.contributor.author | Henderson, MJ | |
dc.contributor.author | Rossing, MA | |
dc.contributor.author | Beeghly-Fadiel, A | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Orsulic, S | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Konecny, GE | |
dc.contributor.author | Huntsman, DG | |
dc.contributor.author | Bowtell, DD | |
dc.contributor.author | Brenton, JD | |
dc.contributor.author | Doherty, JA | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Ramus, SJ | |
dc.date.accessioned | 2020-07-08T10:24:43Z | |
dc.date.issued | 2020-09-01 | |
dc.identifier.citation | Annals of oncology : official journal of the European Society for Medical Oncology, 2020, 31 (9), pp. 1240 - 1250 | |
dc.identifier.issn | 0923-7534 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3824 | |
dc.identifier.eissn | 1569-8041 | |
dc.identifier.doi | 10.1016/j.annonc.2020.05.019 | |
dc.description.abstract | BACKGROUND: Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust prognostic signature for OS in patients with HGSOC. PATIENTS AND METHODS: Expression of 513 genes, selected from a meta-analysis of 1455 tumours and other candidates, was measured using NanoString technology from formalin-fixed paraffin-embedded tumour tissue collected from 3769 women with HGSOC from multiple studies. Elastic net regularization for survival analysis was applied to develop a prognostic model for 5-year OS, trained on 2702 tumours from 15 studies and evaluated on an independent set of 1067 tumours from six studies. RESULTS: Expression levels of 276 genes were associated with OS (false discovery rate < 0.05) in covariate-adjusted single-gene analyses. The top five genes were TAP1, ZFHX4, CXCL9, FBN1 and PTGER3 (P < 0.001). The best performing prognostic signature included 101 genes enriched in pathways with treatment implications. Each gain of one standard deviation in the gene expression score conferred a greater than twofold increase in risk of death [hazard ratio (HR) 2.35, 95% confidence interval (CI) 2.02-2.71; P < 0.001]. Median survival [HR (95% CI)] by gene expression score quintile was 9.5 (8.3 to -), 5.4 (4.6-7.0), 3.8 (3.3-4.6), 3.2 (2.9-3.7) and 2.3 (2.1-2.6) years. CONCLUSION: The OTTA-SPOT (Ovarian Tumor Tissue Analysis consortium - Stratified Prognosis of Ovarian Tumours) gene expression signature may improve risk stratification in clinical trials by identifying patients who are least likely to achieve 5-year survival. The identified novel genes associated with the outcome may also yield opportunities for the development of targeted therapeutic approaches. | |
dc.format | Print-Electronic | |
dc.format.extent | 1240 - 1250 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | AOCS Group | |
dc.subject | Humans | |
dc.subject | Cystadenocarcinoma, Serous | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Prognosis | |
dc.subject | Proportional Hazards Models | |
dc.subject | Survival Analysis | |
dc.subject | Female | |
dc.subject | Transcriptome | |
dc.title | Prognostic gene expression signature for high-grade serous ovarian cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2020-05-06 | |
rioxxterms.versionofrecord | 10.1016/j.annonc.2020.05.019 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
rioxxterms.licenseref.startdate | 2020-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Annals of oncology : official journal of the European Society for Medical Oncology | |
pubs.issue | 9 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Medicine (Brown Epigenetic Therapy) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Medicine (Brown Epigenetic Therapy) | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 31 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Medicine (Brown Epigenetic Therapy) | |
dc.contributor.icrauthor | Brown, Robert | |