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dc.contributor.authorJerome, NP
dc.contributor.authorMiyazaki, K
dc.contributor.authorCollins, DJ
dc.contributor.authorOrton, MR
dc.contributor.authord'Arcy, JA
dc.contributor.authorWallace, T
dc.contributor.authorMoreno, L
dc.contributor.authorPearson, ADJ
dc.contributor.authorMarshall, LV
dc.contributor.authorCarceller, F
dc.contributor.authorLeach, MO
dc.contributor.authorZacharoulis, S
dc.contributor.authorKoh, D-M
dc.date.accessioned2017-01-10T13:42:39Z
dc.date.issued2017-01
dc.identifier.citationEuropean radiology, 2017, 27 (1), pp. 345 - 353
dc.identifier.issn0938-7994
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/387
dc.identifier.eissn1432-1084
dc.identifier.doi10.1007/s00330-016-4318-2
dc.description.abstractObjectives To examine repeatability of parameters derived from non-Gaussian diffusion models in data acquired in children with solid tumours.Methods Paediatric patients (<16 years, n = 17) were scanned twice, 24 h apart, using DWI (6 b-values, 0-1000 mm -2  s) at 1.5 T in a prospective study. Tumour ROIs were drawn (3 slices) and all data fitted using IVIM, stretched exponential, and kurtosis models; percentage coefficients of variation (CV) calculated for each parameter at all ROI histogram centiles, including the medians.Results The values for ADC, D, DDC α , α, and DDC K gave CV < 10 % down to the 5th centile, with sharp CV increases below 5th and above 95th centile. K, f, and D* showed increased CV (>30 %) over the histogram. ADC, D, DDC α , and DDC K were strongly correlated (ρ > 0.9), DDC α and α were not correlated (ρ = 0.083).Conclusion Perfusion- and kurtosis-related parameters displayed larger, more variable CV across the histogram, indicating observed clinical changes outside of D/DDC in these models should be interpreted with caution. Centiles below 5th for all parameters show high CV and are unreliable as diffusion metrics. The stretched exponential model behaved well for both DDC α and α, making it a strong candidate for modelling multiple-b-value diffusion imaging data.Key points • ADC has good repeatability as low 5th centile of the histogram distribution. • High CV was observed for all parameters at extremes of histogram. • Parameters from the stretched exponential model showed low coefficients of variation. • The median ADC, D, DDC α , and DDC K are highly correlated and repeatable. • Perfusion/kurtosis parameters showed high CV variations across their histogram distributions.
dc.formatPrint-Electronic
dc.format.extent345 - 353
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectDiffusion Magnetic Resonance Imaging
dc.subjectCohort Studies
dc.subjectProspective Studies
dc.subjectReproducibility of Results
dc.subjectModels, Theoretical
dc.subjectAdolescent
dc.subjectChild
dc.subjectFemale
dc.subjectMale
dc.titleRepeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort.
dc.typeJournal Article
dcterms.dateAccepted2016-03-02
rioxxterms.versionofrecord10.1007/s00330-016-4318-2
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2017-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfEuropean radiology
pubs.issue1
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Magnetic Resonance
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume27
pubs.embargo.termsNo embargo
icr.researchteamMagnetic Resonanceen_US
dc.contributor.icrauthorMiyazaki, Keikoen
dc.contributor.icrauthorLeach, Martinen
dc.contributor.icrauthorKoh, Dow-Muen
dc.contributor.icrauthorMarsden,en


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