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dc.contributor.authorJäger, Ren_US
dc.contributor.authorMigliorini, Gen_US
dc.contributor.authorHenrion, Men_US
dc.contributor.authorKandaswamy, Ren_US
dc.contributor.authorSpeedy, HEen_US
dc.contributor.authorHeindl, Aen_US
dc.contributor.authorWhiffin, Nen_US
dc.contributor.authorCarnicer, MJen_US
dc.contributor.authorBroome, Len_US
dc.contributor.authorDryden, Nen_US
dc.contributor.authorNagano, Ten_US
dc.contributor.authorSchoenfelder, Sen_US
dc.contributor.authorEnge, Men_US
dc.contributor.authorYuan, Yen_US
dc.contributor.authorTaipale, Jen_US
dc.contributor.authorFraser, Pen_US
dc.contributor.authorFletcher, Oen_US
dc.contributor.authorHoulston, RSen_US
dc.date.accessioned2020-07-28T14:19:26Z
dc.date.issued2015-02-19en_US
dc.identifier.citationNature Communications, 2015, 6 pp. 6178 - ?en_US
dc.identifier.issn2041-1723en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3890
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/ncomms7178en_US
dc.description.abstractMultiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer-promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (cHi-C) approach to allow an agnostic characterization of these physical interactions on a genome-wide scale. Single-nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci allows us to identify key long-range chromatin interactions in cis and trans involving these loci.en_US
dc.formatElectronicen_US
dc.format.extent6178 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCell Line, Tumoren_US
dc.subjectChromosomes, Human, Pair 8en_US
dc.subjectChromatinen_US
dc.subjectHumansen_US
dc.subjectColorectal Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectIn Situ Hybridization, Fluorescenceen_US
dc.subjectRisk Factorsen_US
dc.subjectBase Pairingen_US
dc.subjectStatistics as Topicen_US
dc.subjectGenetic Locien_US
dc.subjectMolecular Sequence Annotationen_US
dc.subjectNucleotide Motifsen_US
dc.titleCapture Hi-C identifies the chromatin interactome of colorectal cancer risk loci.en_US
dc.typeJournal Article
dcterms.dateAccepted2014-12-30en_US
rioxxterms.versionofrecord10.1038/ncomms7178en_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en_US
rioxxterms.licenseref.startdate2015-02-19en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfNature Communicationsen_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Molecular & Population Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Computational Pathology & Integrated Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.publication-statusPublisheden_US
pubs.volume6en_US
pubs.embargo.termsNot knownen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamComputational Pathology & Integrated Genomicsen_US
icr.researchteamGene Functionen_US
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorHoulston, Richarden_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorYuan, Yinyinen_US
dc.contributor.icrauthorWhiffin, Nicolaen_US
dc.contributor.icrauthorBroome, Lauraen_US


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