dc.contributor.author | O'Connor, JPB | |
dc.contributor.author | Jayson, GC | |
dc.date.accessioned | 2020-08-12T10:55:42Z | |
dc.date.issued | 2012-12-15 | |
dc.identifier.citation | Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, 18 (24), pp. 6588 - 6598 | |
dc.identifier.issn | 1078-0432 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3927 | |
dc.identifier.eissn | 1557-3265 | |
dc.identifier.doi | 10.1158/1078-0432.ccr-12-1501 | |
dc.description.abstract | The management of solid tumors has been transformed by the advent of VEGF pathway inhibitors. Early clinical evaluation of these drugs has used pharmacodynamic biomarkers derived from advanced imaging such as dynamic MRI, computed tomography (CT), and ultrasound to establish proof of principle. We have reviewed published studies that used these imaging techniques to determine whether the same biomarkers relate to survival in renal, hepatocellular, and brain tumors in patients treated with VEGF inhibitors. Data show that in renal cancer, pretreatment measurements of K(trans) and early pharmacodynamic reduction in tumor enhancement and density have prognostic significance in patients treated with VEGF inhibitors. A weaker, but significant, relationship is seen with subtle early size change (10% in one dimension) and survival. Data from high-grade glioma suggest that pretreatment fractional blood volume and K(trans) were prognostic of overall survival. However, lack of control data with other therapies prevents assessment of the predictive nature of these biomarkers, and such studies are urgently required. | |
dc.format | Print-Electronic | |
dc.format.extent | 6588 - 6598 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER ASSOC CANCER RESEARCH | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Animals | |
dc.subject | Humans | |
dc.subject | Neoplasms | |
dc.subject | Glioma | |
dc.subject | Carcinoma, Hepatocellular | |
dc.subject | Carcinoma, Renal Cell | |
dc.subject | Liver Neoplasms | |
dc.subject | Brain Neoplasms | |
dc.subject | Kidney Neoplasms | |
dc.subject | Angiogenesis Inhibitors | |
dc.subject | Vascular Endothelial Growth Factor A | |
dc.subject | Treatment Outcome | |
dc.subject | Tumor Burden | |
dc.subject | Biomarkers, Tumor | |
dc.title | Do imaging biomarkers relate to outcome in patients treated with VEGF inhibitors? | |
dc.type | Journal Article | |
rioxxterms.versionofrecord | 10.1158/1078-0432.ccr-12-1501 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2012-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Clinical cancer research : an official journal of the American Association for Cancer Research | |
pubs.issue | 24 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Quantitative Biomedical Imaging | |
pubs.publication-status | Published | |
pubs.volume | 18 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Quantitative Biomedical Imaging | |
dc.contributor.icrauthor | O'Connor, James Patrick | |