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dc.contributor.authorWang, Z
dc.contributor.authorMcGlynn, KA
dc.contributor.authorRajpert-De Meyts, E
dc.contributor.authorBishop, DT
dc.contributor.authorChung, CC
dc.contributor.authorDalgaard, MD
dc.contributor.authorGreene, MH
dc.contributor.authorGupta, R
dc.contributor.authorGrotmol, T
dc.contributor.authorHaugen, TB
dc.contributor.authorKarlsson, R
dc.contributor.authorLitchfield, K
dc.contributor.authorMitra, N
dc.contributor.authorNielsen, K
dc.contributor.authorPyle, LC
dc.contributor.authorSchwartz, SM
dc.contributor.authorThorsson, V
dc.contributor.authorVardhanabhuti, S
dc.contributor.authorWiklund, F
dc.contributor.authorTurnbull, C
dc.contributor.authorChanock, SJ
dc.contributor.authorKanetsky, PA
dc.contributor.authorNathanson, KL
dc.contributor.authorTesticular Cancer Consortium
dc.date.accessioned2020-08-25T15:41:38Z
dc.date.issued2017-07
dc.identifier.citationNature genetics, 2017, 49 (7), pp. 1141 - 1147
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4006
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/ng.3879
dc.description.abstractThe international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We conducted a fixed-effects meta-analysis, including, to our knowledge, the first analysis of the X chromosome. Eight new loci mapping to 2q14.2, 3q26.2, 4q35.2, 7q36.3, 10q26.13, 15q21.3, 15q22.31, and Xq28 achieved genome-wide significance (P < 5 × 10<sup>-8</sup>). Most loci harbor biologically plausible candidate genes. We refined previously reported associations at 9p24.3 and 19p12 by identifying one and three additional independent SNPs, respectively. In aggregate, the 39 independent markers identified to date explain 37% of father-to-son familial risk, 8% of which can be attributed to the 12 new signals reported here. Our findings substantially increase the number of known TGCT susceptibility alleles, move the field closer to a comprehensive understanding of the underlying genetic architecture of TGCT, and provide further clues to the etiology of TGCT.
dc.formatPrint-Electronic
dc.format.extent1141 - 1147
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectTesticular Cancer Consortium
dc.subjectChromosomes, Human, X
dc.subjectHumans
dc.subjectNeoplasms, Germ Cell and Embryonal
dc.subjectTesticular Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectGenetic Markers
dc.subjectRisk
dc.subjectChromosome Mapping
dc.subjectComputational Biology
dc.subjectGenotype
dc.subjectHaplotypes
dc.subjectPolymorphism, Single Nucleotide
dc.subjectComputer Simulation
dc.subjectAdult
dc.subjectFamily Health
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.subjectYoung Adult
dc.titleMeta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.
dc.typeJournal Article
dcterms.dateAccepted2017-04-27
rioxxterms.versionofrecord10.1038/ng.3879
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-07
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue7
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics
pubs.publication-statusPublished
pubs.volume49en_US
pubs.embargo.termsNot known
icr.researchteamMolecular & Population Geneticsen_US
dc.contributor.icrauthorLitchfield, Kevinen
dc.contributor.icrauthorTurnbull, Clareen


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