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dc.contributor.authorLim, K
dc.contributor.authorHalim, A
dc.contributor.authorLu, T-S
dc.contributor.authorAshworth, A
dc.contributor.authorChong, I
dc.date.accessioned2020-09-30T10:12:09Z
dc.date.issued2019-09-19
dc.identifier.citationInternational journal of molecular sciences, 2019, 20 (18)
dc.identifier.issn1422-0067
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4085
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms20184637
dc.description.abstractAccelerated vascular aging is a condition that occurs as a complication of several highly prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and diabetes. Age-associated vascular alterations underlie a continuum of expression toward clinically overt cardiovascular disease. This has contributed to the striking epidemiologic transition whereby such noncommunicable diseases have taken center stage as modern-day global epidemics and public health problems. The identification of α-Klotho, a remarkable protein that confers powerful anti-aging properties has stimulated significant interest. In fact, emerging data have provided fundamental rationale for Klotho-based therapeutic intervention for vascular diseases and multiple other potential indications. However, the application of such discoveries in Klotho research remains fragmented due to significant gaps in our molecular understanding of Klotho biology, as well as hurdles in clinical research and experimental barriers that must first be overcome. These advances will be critical to establish the scientific platform from which future Klotho-based interventional trials and therapeutic enterprises can be successfully launched.
dc.formatElectronic
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectAnimals
dc.subjectHumans
dc.subjectNeoplasms
dc.subjectVascular Diseases
dc.subjectDiabetes Mellitus
dc.subjectGlucuronidase
dc.subjectNeoplasm Proteins
dc.subjectAging
dc.subjectRenal Insufficiency, Chronic
dc.titleKlotho: A Major Shareholder in Vascular Aging Enterprises.
dc.typeJournal Article
dcterms.dateAccepted2019-09-13
rioxxterms.versionofrecord10.3390/ijms20184637
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-09-19
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfInternational journal of molecular sciences
pubs.issue18
pubs.notesNo embargo
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Ashworth Collaborators
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Ashworth Collaborators
pubs.publication-statusPublished
pubs.volume20
pubs.embargo.termsNo embargo
icr.researchteamAshworth Collaboratorsen_US
dc.contributor.icrauthorChong, Yu-Shingen


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