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dc.contributor.authorde Mol van Otterloo, SR
dc.contributor.authorChristodouleas, JP
dc.contributor.authorBlezer, ELA
dc.contributor.authorAkhiat, H
dc.contributor.authorBrown, K
dc.contributor.authorChoudhury, A
dc.contributor.authorEggert, D
dc.contributor.authorErickson, BA
dc.contributor.authorFaivre-Finn, C
dc.contributor.authorFuller, CD
dc.contributor.authorGoldwein, J
dc.contributor.authorHafeez, S
dc.contributor.authorHall, E
dc.contributor.authorHarrington, KJ
dc.contributor.authorvan der Heide, UA
dc.contributor.authorHuddart, RA
dc.contributor.authorIntven, MPW
dc.contributor.authorKirby, AM
dc.contributor.authorLalondrelle, S
dc.contributor.authorMcCann, C
dc.contributor.authorMinsky, BD
dc.contributor.authorMook, S
dc.contributor.authorNowee, ME
dc.contributor.authorOelfke, U
dc.contributor.authorOrrling, K
dc.contributor.authorSahgal, A
dc.contributor.authorSarmiento, JG
dc.contributor.authorSchultz, CJ
dc.contributor.authorTersteeg, RJHA
dc.contributor.authorTijssen, RHN
dc.contributor.authorTree, AC
dc.contributor.authorvan Triest, B
dc.contributor.authorHall, WA
dc.contributor.authorVerkooijen, HM
dc.date.accessioned2020-09-30T14:13:07Z
dc.date.issued2020-01
dc.identifier.citationFrontiers in oncology, 2020, 10 pp. 1328 - ?
dc.identifier.issn2234-943X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4109
dc.identifier.eissn2234-943X
dc.identifier.doi10.3389/fonc.2020.01328
dc.description.abstractPurpose: MR-guided Radiation Therapy (MRgRT) allows for high-precision radiotherapy under real-time MR visualization. This enables margin reduction and subsequent dose escalation which may lead to higher tumor control and less toxicity. The Unity MR-linac (Elekta AB, Stockholm, Sweden) integrates a linear accelerator with a 1.5T diagnostic quality MRI and an online adaptive workflow. A prospective international registry was established to facilitate the evidence-based implementation of the Unity MR-linac into clinical practice, to systemically evaluate long-term outcomes, and to aid further technical development of MR-linac-based MRgRT. Methods and Results: In February 2019, the Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-linac study (MOMENTUM) started within the MR-linac Consortium. The MOMENTUM study is an international academic-industrial partnership between several hospitals and industry partner Elekta. All patients treated on the MR-linac are eligible for inclusion in MOMENTUM. For participants, we collect clinical patient data (e.g., patient, tumor, and treatment characteristics) and technical patient data which is defined as information generated on the MR-linac during treatment. The data are captured, pseudonymized, and stored in an international registry at set time intervals up to two years after treatment. Patients can choose to provide patient-reported outcomes and consent to additional MRI scans acquired on the MR-linac. This registry will serve as a data platform that supports multicenter research investigating the MR-linac. Rules and regulations on data sharing, data access, and intellectual property rights are summarized in an academic-industrial collaboration agreement. Data access rules ensure secure data handling and research integrity for investigators and institutions. Separate data access rules exist for academic and industry partners. This study is registered at ClinicalTrials.gov with ID: NCT04075305 (https://clinicaltrials.gov/ct2/show/NCT04075305). Conclusion: The multi-institutional MOMENTUM study has been set up to collect clinical and technical patient data to advance technical development, and facilitate evidenced-based implementation of MR-linac technology with the ultimate purpose to improve tumor control, survival, and quality of life of patients with cancer.
dc.formatElectronic-eCollection
dc.format.extent1328 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleThe MOMENTUM Study: An International Registry for the Evidence-Based Introduction of MR-Guided Adaptive Therapy.
dc.typeJournal Article
dcterms.dateAccepted2020-06-25
rioxxterms.versionofrecord10.3389/fonc.2020.01328
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2020-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfFrontiers in oncology
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy/Breast Cancer Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer/Gynaecological Cancer (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/ICR-CTSU Urology and Head and Neck Trials Team
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Breast Cancer Radiotherapy/Breast Cancer Radiotherapy (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Clinical Academic Radiotherapy (Huddart)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Gynaecological Cancer/Gynaecological Cancer (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume10
pubs.embargo.termsNot known
icr.researchteamICR-CTSU Urology and Head and Neck Trials Teamen_US
icr.researchteamBreast Cancer Radiotherapyen_US
icr.researchteamClinical Academic Radiotherapy (Huddart)en_US
icr.researchteamGynaecological Canceren_US
icr.researchteamRadiotherapy Physics Modellingen_US
dc.contributor.icrauthorHall, Emmaen
dc.contributor.icrauthorHuddart, Roberten
dc.contributor.icrauthorOelfke, Uween
dc.contributor.icrauthorHafeez, Shaistaen
dc.contributor.icrauthorLalondrelle, Susanen
dc.contributor.icrauthorKirby, Annaen
dc.contributor.icrauthorTree, Alisonen


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