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dc.contributor.authorJi, X
dc.contributor.authorBossé, Y
dc.contributor.authorLandi, MT
dc.contributor.authorGui, J
dc.contributor.authorXiao, X
dc.contributor.authorQian, D
dc.contributor.authorJoubert, P
dc.contributor.authorLamontagne, M
dc.contributor.authorLi, Y
dc.contributor.authorGorlov, I
dc.contributor.authorde Biasi, M
dc.contributor.authorHan, Y
dc.contributor.authorGorlova, O
dc.contributor.authorHung, RJ
dc.contributor.authorWu, X
dc.contributor.authorMcKay, J
dc.contributor.authorZong, X
dc.contributor.authorCarreras-Torres, R
dc.contributor.authorChristiani, DC
dc.contributor.authorCaporaso, N
dc.contributor.authorJohansson, M
dc.contributor.authorLiu, G
dc.contributor.authorBojesen, SE
dc.contributor.authorLe Marchand, L
dc.contributor.authorAlbanes, D
dc.contributor.authorBickeböller, H
dc.contributor.authorAldrich, MC
dc.contributor.authorBush, WS
dc.contributor.authorTardon, A
dc.contributor.authorRennert, G
dc.contributor.authorChen, C
dc.contributor.authorTeare, MD
dc.contributor.authorField, JK
dc.contributor.authorKiemeney, LA
dc.contributor.authorLazarus, P
dc.contributor.authorHaugen, A
dc.contributor.authorLam, S
dc.contributor.authorSchabath, MB
dc.contributor.authorAndrew, AS
dc.contributor.authorShen, H
dc.contributor.authorHong, Y-C
dc.contributor.authorYuan, J-M
dc.contributor.authorBertazzi, PA
dc.contributor.authorPesatori, AC
dc.contributor.authorYe, Y
dc.contributor.authorDiao, N
dc.contributor.authorSu, L
dc.contributor.authorZhang, R
dc.contributor.authorBrhane, Y
dc.contributor.authorLeighl, N
dc.contributor.authorJohansen, JS
dc.contributor.authorMellemgaard, A
dc.contributor.authorSaliba, W
dc.contributor.authorHaiman, C
dc.contributor.authorWilkens, L
dc.contributor.authorFernandez-Somoano, A
dc.contributor.authorFernandez-Tardon, G
dc.contributor.authorvan der Heijden, EHFM
dc.contributor.authorKim, JH
dc.contributor.authorDai, J
dc.contributor.authorHu, Z
dc.contributor.authorDavies, MPA
dc.contributor.authorMarcus, MW
dc.contributor.authorBrunnström, H
dc.contributor.authorManjer, J
dc.contributor.authorMelander, O
dc.contributor.authorMuller, DC
dc.contributor.authorOvervad, K
dc.contributor.authorTrichopoulou, A
dc.contributor.authorTumino, R
dc.contributor.authorDoherty, J
dc.contributor.authorGoodman, GE
dc.contributor.authorCox, A
dc.contributor.authorTaylor, F
dc.contributor.authorWoll, P
dc.contributor.authorBrüske, I
dc.contributor.authorManz, J
dc.contributor.authorMuley, T
dc.contributor.authorRisch, A
dc.contributor.authorRosenberger, A
dc.contributor.authorGrankvist, K
dc.contributor.authorJohansson, M
dc.contributor.authorShepherd, F
dc.contributor.authorTsao, M-S
dc.contributor.authorArnold, SM
dc.contributor.authorHaura, EB
dc.contributor.authorBolca, C
dc.contributor.authorHolcatova, I
dc.contributor.authorJanout, V
dc.contributor.authorKontic, M
dc.contributor.authorLissowska, J
dc.contributor.authorMukeria, A
dc.contributor.authorOgnjanovic, S
dc.contributor.authorOrlowski, TM
dc.contributor.authorScelo, G
dc.contributor.authorSwiatkowska, B
dc.contributor.authorZaridze, D
dc.contributor.authorBakke, P
dc.contributor.authorSkaug, V
dc.contributor.authorZienolddiny, S
dc.contributor.authorDuell, EJ
dc.contributor.authorButler, LM
dc.contributor.authorKoh, W-P
dc.contributor.authorGao, Y-T
dc.contributor.authorHoulston, R
dc.contributor.authorMcLaughlin, J
dc.contributor.authorStevens, V
dc.contributor.authorNickle, DC
dc.contributor.authorObeidat, M
dc.contributor.authorTimens, W
dc.contributor.authorZhu, B
dc.contributor.authorSong, L
dc.contributor.authorArtigas, MS
dc.contributor.authorTobin, MD
dc.contributor.authorWain, LV
dc.contributor.authorGu, F
dc.contributor.authorByun, J
dc.contributor.authorKamal, A
dc.contributor.authorZhu, D
dc.contributor.authorTyndale, RF
dc.contributor.authorWei, W-Q
dc.contributor.authorChanock, S
dc.contributor.authorBrennan, P
dc.contributor.authorAmos, CI
dc.date.accessioned2020-10-06T13:34:28Z
dc.date.issued2018-08-13
dc.identifier.citationNature communications, 2018, 9 (1), pp. 3221 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/4127
dc.identifier.eissn2041-1723en_US
dc.identifier.doi10.1038/s41467-018-05074-yen_US
dc.description.abstractGenome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer.
dc.formatElectronic
dc.format.extent3221 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectChromosomes, Human, Pair 15
dc.subjectHumans
dc.subjectLung Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectReproducibility of Results
dc.subjectSmoking
dc.subjectPolymorphism, Single Nucleotide
dc.subjectQuantitative Trait Loci
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectFemale
dc.subjectMale
dc.subjectGene Regulatory Networks
dc.subjectYoung Adult
dc.subjectGene Ontology
dc.titleIdentification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk.
dc.typeJournal Article
dcterms.dateAccepted2018-05-01
rioxxterms.versionofrecord10.1038/s41467-018-05074-y
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-08-13en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.publication-statusPublished
pubs.volume9en_US
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
dc.contributor.icrauthorHoulston, Richarden


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