dc.contributor.author | Führes, T | |
dc.contributor.author | Riexinger, AJ | |
dc.contributor.author | Loh, M | |
dc.contributor.author | Martin, J | |
dc.contributor.author | Wetscherek, A | |
dc.contributor.author | Kuder, TA | |
dc.contributor.author | Uder, M | |
dc.contributor.author | Hensel, B | |
dc.contributor.author | Laun, FB | |
dc.date.accessioned | 2021-11-25T13:20:15Z | |
dc.date.available | 2021-11-25T13:20:15Z | |
dc.date.issued | 2021-08-28 | |
dc.identifier.citation | Magnetic resonance in medicine, 2021 | |
dc.identifier.issn | 0740-3194 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4898 | |
dc.identifier.eissn | 1522-2594 | |
dc.identifier.doi | 10.1002/mrm.28996 | |
dc.description.abstract | PURPOSE: Intravoxel incoherent motion (IVIM) studies are performed with different acquisition protocols. Comparing them requires knowledge of echo time (TE) dependencies. The TE-dependence of the biexponential perfusion fraction f is well-documented, unlike that of its triexponential counterparts f1 and f2 and the biexponential and triexponential pseudodiffusion coefficients D* , D1∗ , and D2∗ . The purpose was to investigate the TE-dependence of these parameters and to check whether the triexponential pseudodiffusion compartments are associated with arterial and venous blood. METHODS: Fifteen healthy volunteers (19-58 y; mean: 24.7 y) underwent diffusion-weighted imaging of the abdomen with 24 b-values (0.2-800 s/mm2 ) at TEs of 45, 60, 75, and 90 ms. Regions of interest (ROIs) were manually drawn in the liver. One set of bi- and triexponential IVIM parameters per volunteer and TE was determined. The TE-dependence was assessed with the Kruskal-Wallis test. RESULTS: TE-dependence was observed for f (P < .001), f1 (P = .001), and f2 (P < .001). Their median values at the four measured TEs were: f: 0.198/0.240/0.274/0.359, f1 : 0.113/0.139/0.146/0.205, f2 : 0.115/0.155/0.182/0.194. D, D* , D1∗ , and D2∗ showed no significant TE-dependence. Their values were: diffusion coefficient D (10-4 mm2 /s): 9.45/9.63/9.75/9.41, biexponential D* (10-2 mm2 /s): 5.26/5.52/6.13/5.82, triexponential D1∗ (10-2 mm2 /s): 1.73/2.91/2.25/2.51, triexponential D2∗ (mm2 /s): 0.478/1.385/0.616/0.846. CONCLUSION: f1 and f2 show similar TE-dependence as f, ie, increase with rising TE; an effect that must be accounted for when comparing different studies. The diffusion and pseudodiffusion coefficients might be compared without TE correction. Because of the similar TE-dependence of f1 and f2 , the triexponential pseudodiffusion compartments are most probably not associated to venous and arterial blood. | |
dc.format | Print-Electronic | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | WILEY | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Echo time dependence of biexponential and triexponential intravoxel incoherent motion parameters in the liver. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-08-12 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1002/mrm.28996 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2021-08-28 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Magnetic resonance in medicine | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.publication-status | Published | |
pubs.embargo.terms | Not known | |
icr.researchteam | Radiotherapy Physics Modelling | |
dc.contributor.icrauthor | Wetscherek, Andreas | |