dc.contributor.author | Gupta, A | |
dc.contributor.author | Dunlop, A | |
dc.contributor.author | Mitchell, A | |
dc.contributor.author | McQuaid, D | |
dc.contributor.author | Nill, S | |
dc.contributor.author | Barnes, H | |
dc.contributor.author | Newbold, K | |
dc.contributor.author | Nutting, C | |
dc.contributor.author | Bhide, S | |
dc.contributor.author | Oelfke, U | |
dc.contributor.author | Harrington, KJ | |
dc.contributor.author | Wong, KH | |
dc.date.accessioned | 2022-01-25T13:34:20Z | |
dc.date.available | 2022-01-25T13:34:20Z | |
dc.date.issued | 2021-11-19 | |
dc.identifier.citation | Clinical and translational radiation oncology, 2022, 32 pp. 48 - 51 | |
dc.identifier.issn | 2405-6308 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/4973 | |
dc.identifier.eissn | 2405-6308 | |
dc.identifier.eissn | 2405-6308 | |
dc.identifier.doi | 10.1016/j.ctro.2021.11.001 | |
dc.identifier.doi | 10.1016/j.ctro.2021.11.001 | |
dc.description.abstract | INTRODUCTION: The Elekta Unity MR-Linac (MRL) has enabled adaptive radiotherapy (ART) for patients with head and neck cancers (HNC). Adapt-To-Shape-Lite (ATS-Lite) is a novel Adapt-to-Shape strategy that provides ART without requiring daily clinician presence to perform online target and organ at risk (OAR) delineation. In this study we compared the performance of our clinically-delivered ATS-Lite strategy against three Adapt-To-Position (ATP) variants: Adapt Segments (ATP-AS), Optimise Weights (ATP-OW), and Optimise Shapes (ATP-OS). METHODS: Two patients with HNC received radical-dose radiotherapy on the MRL. For each fraction, an ATS-Lite plan was generated online and delivered and additional plans were generated offline for each ATP variant. To assess the clinical acceptability of a plan for every fraction, twenty clinical goals for targets and OARs were assessed for all four plans. RESULTS: 53 fractions were analysed. ATS-Lite passed 99.9% of mandatory dose constraints. ATP-AS and ATP-OW each failed 7.6% of mandatory dose constraints. The Planning Target Volumes for 54 Gy (D95% and D98%) were the most frequently failing dose constraint targets for ATP. ATS-Lite median fraction times for Patient 1 and 2 were 40 mins 9 s (range 28 mins 16 s - 47 mins 20 s) and 32 mins 14 s (range 25 mins 33 s - 44 mins 27 s), respectively. CONCLUSIONS: Our early data show that the novel ATS-Lite strategy produced plans that fulfilled 99.9% of clinical dose constraints in a time frame that is tolerable for patients and comparable to ATP workflows. Therefore, ATS-Lite, which bridges the gap between ATP and full ATS, will be further utilised and developed within our institute and it is a workflow that should be considered for treating patients with HNC on the MRL. | |
dc.format | Electronic-eCollection | |
dc.format.extent | 48 - 51 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ELSEVIER IRELAND LTD | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.title | Online adaptive radiotherapy for head and neck cancers on the MR linear Accelerator: Introducing a novel modified Adapt-to-Shape approach. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2021-11-04 | |
rioxxterms.version | VoR | |
rioxxterms.versionofrecord | 10.1016/j.ctro.2021.11.001 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0 | |
dc.relation.isPartOf | Clinical and translational radiation oncology | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/ImmNet | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Radiotherapy Physics Modelling | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.publication-status | Published | |
pubs.volume | 32 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Radiotherapy Physics Modelling | |
icr.researchteam | Targeted Therapy | |
dc.contributor.icrauthor | Nill, Simeon | |
dc.contributor.icrauthor | Bhide, Shreerang | |
dc.contributor.icrauthor | Harrington, Kevin | |