Now showing items 1-2 of 2

    • Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors. 

      Tornatore, L; Sandomenico, A; Raimondo, D; Low, C; Rocci, A; Tralau-Stewart, C; Capece, D; D'Andrea, D; Bua, M; Boyle, E; van Duin, M; Zoppoli, P; Jaxa-Chamiec, A; Thotakura, AK; Dyson, J; Walker, BA; Leonardi, A; Chambery, A; Driessen, C; Sonneveld, P; Morgan, G; Palumbo, A; Tramontano, A; Rahemtulla, A; Ruvo, M; Franzoso, G (2014-10)
      Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell specificity. Here, we identify the interaction between the NF-κB-regulated ...
    • Pixantrone: a novel anthracycline-like drug for the treatment of non-Hodgkin lymphoma 

      Boyle, Eileen Mary (2015-04)
      Introduction: The current treatment approach of high-grade non-Hodgkin lymphoma (NHL) relies to a large extent on anthracycline-based regimens yielding cure rates in similar to 65 - 75% of patients. Despite being highly ...