Now showing items 1-7 of 7

    • PET-PANC: multicentre prospective diagnostic accuracy and health economic analysis study of the impact of combined modality 18fluorine-2-fluoro-2-deoxy-d-glucose positron emission tomography with computed tomography scanning in the diagnosis and management of pancreatic cancer. 

      Ghaneh, P; Hanson, R; Titman, A; Lancaster, G; Plumpton, C; Lloyd-Williams, H; Yeo, ST; Edwards, RT; Johnson, C; Abu Hilal, M; Higginson, AP; Armstrong, T; Smith, A; Scarsbrook, A; McKay, C; Carter, R; Sutcliffe, RP; Bramhall, S; Kocher, HM; Cunningham, D; Pereira, SP; Davidson, B; Chang, D; Khan, S; Zealley, I; Sarker, D; Al Sarireh, B; Charnley, R; Lobo, D; Nicolson, M; Halloran, C; Raraty, M; Sutton, R; Vinjamuri, S; Evans, J; Campbell, F; Deeks, J; Sanghera, B; Wong, W-L; Neoptolemos, JP (2018-02)
      BACKGROUND:Pancreatic cancer diagnosis and staging can be difficult in 10-20% of patients. Positron emission tomography (PET)/computed tomography (CT) adds precise anatomical localisation to functional data. The use of ...
    • Rationale for Modernising Imaging in Advanced Prostate Cancer. 

      Padhani, AR; Lecouvet, FE; Tunariu, N; Koh, D-M; De Keyzer, F; Collins, DJ; Sala, E; Fanti, S; Vargas, HA; Petralia, G; Petralia, G; Schlemmer, HP; Tombal, B; de Bono, J (2017-04)
      CONTEXT:To effectively manage patients with advanced prostate cancer (APC), it is essential to have accurate, reproducible, and validated methods for detecting and quantifying the burden of bone and soft tissue metastases ...
    • Reversing resistance to targeted therapy. 

      Vidal, L; Attard, G; Kaye, S; De Bono, J (2004-11)
      The development of molecular targeted anticancer drugs is rapidly changing cancer therapeutics. However, drug resistance to these novel agents remains a real clinical concern. Reports now indicate that resistance to many ...
    • A Specific Distress Cutoff Score Shortly After Breast Cancer Diagnosis. 

      Ploos van Amstel, FK; Tol, J; Sessink, KH; van der Graaf, WTA; Prins, JB; Ottevanger, PB (2017-05)
      <label>BACKGROUND</label>High levels of distress are expected shortly after the diagnosis breast cancer. The Distress Thermometer (DT) is commonly used to screen for distress, using a cutoff score of 4 or 5; however, this ...
    • The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities. 

      Noujaim, J; Jones, RL; Swansbury, J; Gonzalez, D; Benson, C; Judson, I; Fisher, C; Thway, K (2017-02)
      EWSR1 rearrangements were first identified in Ewing sarcoma, but the spectrum of EWSR1-rearranged neoplasms now includes many soft tissue tumour subtypes including desmoplastic small round cell tumour (DSRCT), myxoid ...
    • The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS). 

      Leach, MO; Eeles, RA; Turnbull, LW; Dixon, AK; Brown, J; Hoff, RJC; Coulthard, A; Dixon, JM; Easton, DF; Evans, DGR; Gilbert, FJ; Hawnaur, J; Hayes, C; Kessar, P; Lakhani, S; Liney, G; Moss, SM; Padhani, AP; Pointon, LJ; Sydenham, M; Walker, LG; Warren, RML; Haites, NE; Morrison, P; Cole, T; Rayter, Z; Donaldson, A; Shere, M; Rankin, J; Goudie, D; Steel, CM; Davidson, R; Chu, C; Ellis, I; Mackay, J; Hodgson, SV; Homfray, T; Douglas, F; Quarrell, OW; Eccles, DM; Gilbert, FG; Crothers, G; Walker, CP; Jones, A; Slack, N; Britton, P; Sheppard, DG; Walsh, J; Whitehouse, G; Teh, W; Rankin, S; Boggis, C; Potterton, J; McLean, L; Gordon, PAL; Rubin, C; Magnetic Resonance Imaging as a Method of Screening for Breast Cancer Advisory Group (2002-09)
      The UK national study of magnetic resonance imaging as a method of screening for breast cancer (MARIBS) is in progress. The study design, accrual to date, and related research projects are described. Revised accrual rates ...
    • Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing. 

      Mansukhani, S; Barber, LJ; Kleftogiannis, D; Moorcraft, SY; Davidson, M; Woolston, A; Proszek, PZ; Griffiths, B; Fenwick, K; Herman, B; Matthews, N; O'Leary, B; Hulkki, S; Gonzalez De Castro, D; Patel, A; Wotherspoon, A; Okachi, A; Rana, I; Begum, R; Davies, MN; Powles, T; von Loga, K; Hubank, M; Turner, N; Watkins, D; Chau, I; Cunningham, D; Lise, S; Starling, N; Gerlinger, M (2018-11)
      BACKGROUND:Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes, but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. ...