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dc.contributor.authorAhearn, TU
dc.contributor.authorZhang, H
dc.contributor.authorMichailidou, K
dc.contributor.authorMilne, RL
dc.contributor.authorBolla, MK
dc.contributor.authorDennis, J
dc.contributor.authorDunning, AM
dc.contributor.authorLush, M
dc.contributor.authorWang, Q
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorArndt, V
dc.contributor.authorAronson, KJ
dc.contributor.authorAuer, PL
dc.contributor.authorAugustinsson, A
dc.contributor.authorBaten, A
dc.contributor.authorBecher, H
dc.contributor.authorBehrens, S
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBlomqvist, C
dc.contributor.authorBojesen, SE
dc.contributor.authorBonanni, B
dc.contributor.authorBørresen-Dale, A-L
dc.contributor.authorBrauch, H
dc.contributor.authorBrenner, H
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorBrüning, T
dc.contributor.authorBurwinkel, B
dc.contributor.authorBuys, SS
dc.contributor.authorCanzian, F
dc.contributor.authorCastelao, JE
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, SJ
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorClarke, CL
dc.contributor.authorNBCS Collaborators,
dc.contributor.authorCollée, JM
dc.contributor.authorCox, A
dc.contributor.authorCross, SS
dc.contributor.authorCzene, K
dc.contributor.authorDaly, MB
dc.contributor.authorDevilee, P
dc.contributor.authorDörk, T
dc.contributor.authorDwek, M
dc.contributor.authorEccles, DM
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFigueroa, J
dc.contributor.authorFloris, G
dc.contributor.authorGago-Dominguez, M
dc.contributor.authorGapstur, SM
dc.contributor.authorGarcía-Sáenz, JA
dc.contributor.authorGaudet, MM
dc.contributor.authorGiles, GG
dc.contributor.authorGoldberg, MS
dc.contributor.authorGonzález-Neira, A
dc.contributor.authorAlnæs, GIG
dc.contributor.authorGrip, M
dc.contributor.authorGuénel, P
dc.contributor.authorHaiman, CA
dc.contributor.authorHall, P
dc.contributor.authorHamann, U
dc.contributor.authorHarkness, EF
dc.contributor.authorHeemskerk-Gerritsen, BAM
dc.contributor.authorHolleczek, B
dc.contributor.authorHollestelle, A
dc.contributor.authorHooning, MJ
dc.contributor.authorHoover, RN
dc.contributor.authorHopper, JL
dc.contributor.authorHowell, A
dc.contributor.authorABCTB Investigators,
dc.contributor.authorkConFab/AOCS Investigators,
dc.contributor.authorJakimovska, M
dc.contributor.authorJakubowska, A
dc.contributor.authorJohn, EM
dc.contributor.authorJones, ME
dc.contributor.authorJung, A
dc.contributor.authorKaaks, R
dc.contributor.authorKauppila, S
dc.contributor.authorKeeman, R
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKitahara, CM
dc.contributor.authorKo, Y-D
dc.contributor.authorKoutros, S
dc.contributor.authorKristensen, VN
dc.contributor.authorKrüger, U
dc.contributor.authorKubelka-Sabit, K
dc.contributor.authorKurian, AW
dc.contributor.authorKyriacou, K
dc.contributor.authorLambrechts, D
dc.contributor.authorLee, DG
dc.contributor.authorLindblom, A
dc.contributor.authorLinet, M
dc.contributor.authorLissowska, J
dc.contributor.authorLlaneza, A
dc.contributor.authorLo, W-Y
dc.contributor.authorMacInnis, RJ
dc.contributor.authorMannermaa, A
dc.contributor.authorManoochehri, M
dc.contributor.authorMargolin, S
dc.contributor.authorMartinez, ME
dc.contributor.authorMcLean, C
dc.contributor.authorMeindl, A
dc.contributor.authorMenon, U
dc.contributor.authorNevanlinna, H
dc.contributor.authorNewman, WG
dc.contributor.authorNodora, J
dc.contributor.authorOffit, K
dc.contributor.authorOlsson, H
dc.contributor.authorOrr, N
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPatel, AV
dc.contributor.authorPeto, J
dc.contributor.authorPita, G
dc.contributor.authorPlaseska-Karanfilska, D
dc.contributor.authorPrentice, R
dc.contributor.authorPunie, K
dc.contributor.authorPylkäs, K
dc.contributor.authorRadice, P
dc.contributor.authorRennert, G
dc.contributor.authorRomero, A
dc.contributor.authorRüdiger, T
dc.contributor.authorSaloustros, E
dc.contributor.authorSampson, S
dc.contributor.authorSandler, DP
dc.contributor.authorSawyer, EJ
dc.contributor.authorSchmutzler, RK
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSchöttker, B
dc.contributor.authorSherman, ME
dc.contributor.authorShu, X-O
dc.contributor.authorSmichkoska, S
dc.contributor.authorSouthey, MC
dc.contributor.authorSpinelli, JJ
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorTamimi, RM
dc.contributor.authorTapper, WJ
dc.contributor.authorTaylor, JA
dc.contributor.authorTeras, LR
dc.contributor.authorTerry, MB
dc.contributor.authorTorres, D
dc.contributor.authorTroester, MA
dc.contributor.authorVachon, CM
dc.contributor.authorvan Deurzen, CHM
dc.contributor.authorvan Veen, EM
dc.contributor.authorWagner, P
dc.contributor.authorWeinberg, CR
dc.contributor.authorWendt, C
dc.contributor.authorWesseling, J
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorYang, XR
dc.contributor.authorZheng, W
dc.contributor.authorCouch, FJ
dc.contributor.authorSimard, J
dc.contributor.authorKraft, P
dc.contributor.authorEaston, DF
dc.contributor.authorPharoah, PDP
dc.contributor.authorSchmidt, MK
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorChatterjee, N
dc.date.accessioned2022-03-22T09:31:36Z
dc.date.available2022-03-22T09:31:36Z
dc.date.issued2022-01-04
dc.identifier.citationBreast cancer research : BCR, 2022, 24 (1), pp. 2 - ?
dc.identifier.issn1465-5411
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5044
dc.identifier.eissn1465-542X
dc.identifier.eissn1465-542X
dc.identifier.doi10.1186/s13058-021-01484-x
dc.identifier.doi10.1186/s13058-021-01484-x
dc.description.abstractBACKGROUND: Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. METHODS: Among 106,571 invasive breast cancer cases and 95,762 controls of European ancestry with data on 173 breast cancer variants identified in previous GWAS, we used novel two-stage polytomous logistic regression models to evaluate variants in relation to multiple tumor features (ER, progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and grade) adjusting for each other, and to intrinsic-like subtypes. RESULTS: Eighty-five of 173 variants were associated with at least one tumor feature (false discovery rate < 5%), most commonly ER and grade, followed by PR and HER2. Models for intrinsic-like subtypes found nearly all of these variants (83 of 85) associated at p < 0.05 with risk for at least one luminal-like subtype, and approximately half (41 of 85) of the variants were associated with risk of at least one non-luminal subtype, including 32 variants associated with triple-negative (TN) disease. Ten variants were associated with risk of all subtypes in different magnitude. Five variants were associated with risk of luminal A-like and TN subtypes in opposite directions. CONCLUSION: This report demonstrates a high level of complexity in the etiology heterogeneity of breast cancer susceptibility variants and can inform investigations of subtype-specific risk prediction.
dc.formatElectronic
dc.format.extent2 - ?
dc.languageeng
dc.language.isoeng
dc.publisherBMC
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectNBCS Collaborators
dc.subjectABCTB Investigators
dc.subjectkConFab/AOCS Investigators
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectReceptor, erbB-2
dc.subjectReceptors, Estrogen
dc.subjectReceptors, Progesterone
dc.subjectRisk
dc.subjectFemale
dc.subjectGenome-Wide Association Study
dc.subjectBiomarkers, Tumor
dc.titleCommon variants in breast cancer risk loci predispose to distinct tumor subtypes.
dc.typeJournal Article
dcterms.dateAccepted2021-11-02
rioxxterms.versionVoR
rioxxterms.versionofrecord10.1186/s13058-021-01484-x
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2022-01-04
dc.relation.isPartOfBreast cancer research : BCR
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.publication-statusPublished
pubs.volume24
pubs.embargo.termsNot known
icr.researchteamAetiological Epidemiology
dc.contributor.icrauthorJones, Michael
dc.contributor.icrauthorSchoemaker, Minouk


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